Regulation of Th2 responses by Lactococcus lactis subsp. cremoris YRC3780 alleviates DNCB-induced atopic dermatitis in the mouse model

• Published in: Journal of functional foods Vol. 94; p. 105091
• Main Authors: Wang, Rong, Nakajima-Adachi, Haruyo, Wang, Yimei, Zhou, Yingyu, Gu, Wenting, Hiraide, Erika, Morinaga, Mamiko, Nakagawa, Ryogo, Nakamura, Shotaro, Takano, Tomohiro, Li, Xuyang, Saeki, Mayumi, Kaminuma, Osamu, Hiroi, Takachika, Uchida, Kenji, Motoshima, Hidemasa, Tanokura, Masaru, Miyakawa, Takuya, Hachimura, Satoshi
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.07.2022
• Subjects: anti-allergic agents; Atopic dermatitis; blood serum; Cytokines; gene expression; IgE; immune response; interleukin-12; interleukin-4; intestines; kefir; Lactococcus lactis subsp. cremoris; lymph; mice; oral administration; Th1-Th2 balance; Lactococcus lactis subsp. cremoris; Th1-Th2 balance; Cytokines; Atopic dermatitis; IgE

[Display omitted] •L. cremoris YRC3780 acted on various types of immune cells to inhibit IL-4.•L. cremoris YRC3780 regulated Th1/Th2 balance in intestinal DC-T cell coculture.•Oral administration of L. cremoris YRC3780 alleviated symptoms in AD mice.•L. cremoris YRC3780 inhibited IL-4 in Peyer’s pat...