Regulation of Th2 responses by Lactococcus lactis subsp. cremoris YRC3780 alleviates DNCB-induced atopic dermatitis in the mouse model

[Display omitted] •L. cremoris YRC3780 acted on various types of immune cells to inhibit IL-4.•L. cremoris YRC3780 regulated Th1/Th2 balance in intestinal DC-T cell coculture.•Oral administration of L. cremoris YRC3780 alleviated symptoms in AD mice.•L. cremoris YRC3780 inhibited IL-4 in Peyer’s pat...

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Published inJournal of functional foods Vol. 94; p. 105091
Main Authors Wang, Rong, Nakajima-Adachi, Haruyo, Wang, Yimei, Zhou, Yingyu, Gu, Wenting, Hiraide, Erika, Morinaga, Mamiko, Nakagawa, Ryogo, Nakamura, Shotaro, Takano, Tomohiro, Li, Xuyang, Saeki, Mayumi, Kaminuma, Osamu, Hiroi, Takachika, Uchida, Kenji, Motoshima, Hidemasa, Tanokura, Masaru, Miyakawa, Takuya, Hachimura, Satoshi
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.07.2022
Subjects
anti-allergic agents
Atopic dermatitis
blood serum
Cytokines
gene expression
IgE
immune response
interleukin-12
interleukin-4
intestines
kefir
Lactococcus lactis subsp. cremoris
lymph
mice
oral administration
Th1-Th2 balance
Lactococcus lactis subsp. cremoris
Th1-Th2 balance
Cytokines
Atopic dermatitis
IgE
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Abstract [Display omitted] •L. cremoris YRC3780 acted on various types of immune cells to inhibit IL-4.•L. cremoris YRC3780 regulated Th1/Th2 balance in intestinal DC-T cell coculture.•Oral administration of L. cremoris YRC3780 alleviated symptoms in AD mice.•L. cremoris YRC3780 inhibited IL-4 in Peyer’s patch CD4+ T cells of AD mice. Lactococcus lactis subsp. cremoris YRC3780 (L. cremoris YRC3780) was isolated from kefir, and anti-allergic effects have been confirmed in humans. The mechanisms by which L. cremoris YRC3780 affects the Th1/Th2 balance in mice were investigated in vitro, focusing on the intestinal immune response. Simultaneously, a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model was used to evaluate the symptom improvement effect of oral administration of L. cremoris YRC3780. The results showed that L. cremoris YRC3780 enhanced IFN-γ and IL-12 production and inhibited IL-4 production from CD4+ T cells in the presence of various types of immune cells. Oral administration of L. cremoris YRC3780 attenuated serum total IgE (p < 0.05) and decreased ear thickness (p < 0.05) in the atopic dermatitis model. The examination of cytokine expression suggested that L. cremoris YRC3780 improved AD-like symptoms by inhibiting IL-4 gene expression from Peyer's patches CD4+ T cells (p < 0.01) and IL-33 gene expression (p < 0.05) in the draining lymph nodes.
AbstractList Lactococcus lactis subsp. cremoris YRC3780 (L. cremoris YRC3780) was isolated from kefir, and anti-allergic effects have been confirmed in humans. The mechanisms by which L. cremoris YRC3780 affects the Th1/Th2 balance in mice were investigated in vitro, focusing on the intestinal immune response. Simultaneously, a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model was used to evaluate the symptom improvement effect of oral administration of L. cremoris YRC3780. The results showed that L. cremoris YRC3780 enhanced IFN-γ and IL-12 production and inhibited IL-4 production from CD4⁺ T cells in the presence of various types of immune cells. Oral administration of L. cremoris YRC3780 attenuated serum total IgE (p < 0.05) and decreased ear thickness (p < 0.05) in the atopic dermatitis model. The examination of cytokine expression suggested that L. cremoris YRC3780 improved AD-like symptoms by inhibiting IL-4 gene expression from Peyer's patches CD4⁺ T cells (p < 0.01) and IL-33 gene expression (p < 0.05) in the draining lymph nodes.
[Display omitted] •L. cremoris YRC3780 acted on various types of immune cells to inhibit IL-4.•L. cremoris YRC3780 regulated Th1/Th2 balance in intestinal DC-T cell coculture.•Oral administration of L. cremoris YRC3780 alleviated symptoms in AD mice.•L. cremoris YRC3780 inhibited IL-4 in Peyer’s patch CD4+ T cells of AD mice. Lactococcus lactis subsp. cremoris YRC3780 (L. cremoris YRC3780) was isolated from kefir, and anti-allergic effects have been confirmed in humans. The mechanisms by which L. cremoris YRC3780 affects the Th1/Th2 balance in mice were investigated in vitro, focusing on the intestinal immune response. Simultaneously, a 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model was used to evaluate the symptom improvement effect of oral administration of L. cremoris YRC3780. The results showed that L. cremoris YRC3780 enhanced IFN-γ and IL-12 production and inhibited IL-4 production from CD4+ T cells in the presence of various types of immune cells. Oral administration of L. cremoris YRC3780 attenuated serum total IgE (p < 0.05) and decreased ear thickness (p < 0.05) in the atopic dermatitis model. The examination of cytokine expression suggested that L. cremoris YRC3780 improved AD-like symptoms by inhibiting IL-4 gene expression from Peyer's patches CD4+ T cells (p < 0.01) and IL-33 gene expression (p < 0.05) in the draining lymph nodes.
ArticleNumber 105091
Author Motoshima, Hidemasa
Li, Xuyang
Hiroi, Takachika
Hiraide, Erika
Wang, Rong
Morinaga, Mamiko
Saeki, Mayumi
Hachimura, Satoshi
Gu, Wenting
Tanokura, Masaru
Nakamura, Shotaro
Uchida, Kenji
Nakagawa, Ryogo
Wang, Yimei
Miyakawa, Takuya
Takano, Tomohiro
Kaminuma, Osamu
Nakajima-Adachi, Haruyo
Zhou, Yingyu
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  givenname: Haruyo
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  fullname: Nakajima-Adachi, Haruyo
  organization: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
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  givenname: Yimei
  surname: Wang
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  organization: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
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  givenname: Yingyu
  surname: Zhou
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  givenname: Wenting
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  givenname: Erika
  surname: Hiraide
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  givenname: Mamiko
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  surname: Li
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  givenname: Mayumi
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  surname: Kaminuma
  fullname: Kaminuma, Osamu
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  surname: Hiroi
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  givenname: Kenji
  surname: Uchida
  fullname: Uchida, Kenji
  organization: R&D Center, Yotsuba Milk Products Co., Ltd., Wattsu 465-1, Kitahiroshima, Hokkaido 061-1264, Japan
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  givenname: Hidemasa
  surname: Motoshima
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  organization: R&D Center, Yotsuba Milk Products Co., Ltd., Wattsu 465-1, Kitahiroshima, Hokkaido 061-1264, Japan
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  givenname: Masaru
  surname: Tanokura
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  email: amtanok@mail.ecc.u-tokyo.ac.jp
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  surname: Miyakawa
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  givenname: Satoshi
  surname: Hachimura
  fullname: Hachimura, Satoshi
  email: ahachi@mail.ecc.u-tokyo.ac.jp
  organization: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
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Keywords Lactococcus lactis subsp. cremoris
Th1-Th2 balance
Cytokines
Atopic dermatitis
IgE
Language English
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Snippet [Display omitted] •L. cremoris YRC3780 acted on various types of immune cells to inhibit IL-4.•L. cremoris YRC3780 regulated Th1/Th2 balance in intestinal DC-T...
Lactococcus lactis subsp. cremoris YRC3780 (L. cremoris YRC3780) was isolated from kefir, and anti-allergic effects have been confirmed in humans. The...
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SubjectTerms anti-allergic agents
Atopic dermatitis
blood serum
Cytokines
gene expression
IgE
immune response
interleukin-12
interleukin-4
intestines
kefir
Lactococcus lactis subsp. cremoris
lymph
mice
oral administration
Th1-Th2 balance
Title Regulation of Th2 responses by Lactococcus lactis subsp. cremoris YRC3780 alleviates DNCB-induced atopic dermatitis in the mouse model
URI https://dx.doi.org/10.1016/j.jff.2022.105091
https://www.proquest.com/docview/2675576654
Volume 94
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