Evaluation of Spheroid 3D Culture Methods to Study a Pancreatic Neuroendocrine Neoplasm Cell Line

• Published in: Frontiers in endocrinology (Lausanne) Vol. 10; p. 682
• Main Authors: Bresciani, Giulia, Hofland, Leo J., Dogan, Fadime, Giamas, Georgios, Gagliano, Teresa, Zatelli, Maria Chiara
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 04.10.2019
• Subjects: 3D culture; BON1; Endocrinology; pancreatic neuroendocrine neoplasms; spheroids; Sunitinib

Pancreatic Neuroendocrine Neoplasms (pNEN) are rare tumors which treatment still represent an important clinical problem, due to the paucity of medical treatments. Due to tumor complexity, techniques as 3D cultures are important to study drug activity in a more realistic model. This study aims to co...