Magnetic resonance imaging relaxation time in Alzheimer’s disease

•T1 and T2 relaxation times in brain tissue.•Applications of T1 and T2 relaxation time in AD (AD patients and mouse models).•Possible mechanisms of T1 and T2 relaxation time alterations in AD. The magnetic resonance imaging (MRI) relaxation time constants, T1 and T2, are sensitive to changes in brai...

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Published inBrain research bulletin Vol. 140; pp. 176 - 189
Main Authors Tang, Xiang, Cai, Feng, Ding, Dong-Xue, Zhang, Lu-Lu, Cai, Xiu-Ying, Fang, Qi
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.06.2018
Subjects
Alzheimer’s disease
Biomarker
Magnetic resonance imaging
T1 relaxation time
T2 relaxation time
Biomarker
Magnetic resonance imaging
T1 relaxation time
Alzheimer’s disease
T2 relaxation time
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Abstract •T1 and T2 relaxation times in brain tissue.•Applications of T1 and T2 relaxation time in AD (AD patients and mouse models).•Possible mechanisms of T1 and T2 relaxation time alterations in AD. The magnetic resonance imaging (MRI) relaxation time constants, T1 and T2, are sensitive to changes in brain tissue microstructure integrity. Quantitative T1 and T2 relaxation times have been proposed to serve as non-invasive biomarkers of Alzheimer’s disease (AD), in which alterations are believed to not only reflect AD-related neuropathology but also cognitive impairment. In this review, we summarize the applications and key findings of MRI techniques in the context of both AD subjects and AD transgenic mouse models. Furthermore, the possible mechanisms of relaxation time alterations in AD will be discussed. Future studies could focus on relaxation time alterations in the early stage of AD, and longitudinal studies are needed to further explore relaxation time alterations during disease progression.
AbstractList •T1 and T2 relaxation times in brain tissue.•Applications of T1 and T2 relaxation time in AD (AD patients and mouse models).•Possible mechanisms of T1 and T2 relaxation time alterations in AD. The magnetic resonance imaging (MRI) relaxation time constants, T1 and T2, are sensitive to changes in brain tissue microstructure integrity. Quantitative T1 and T2 relaxation times have been proposed to serve as non-invasive biomarkers of Alzheimer’s disease (AD), in which alterations are believed to not only reflect AD-related neuropathology but also cognitive impairment. In this review, we summarize the applications and key findings of MRI techniques in the context of both AD subjects and AD transgenic mouse models. Furthermore, the possible mechanisms of relaxation time alterations in AD will be discussed. Future studies could focus on relaxation time alterations in the early stage of AD, and longitudinal studies are needed to further explore relaxation time alterations during disease progression.
The magnetic resonance imaging (MRI) relaxation time constants, T1 and T2, are sensitive to changes in brain tissue microstructure integrity. Quantitative T1 and T2 relaxation times have been proposed to serve as non-invasive biomarkers of Alzheimer's disease (AD), in which alterations are believed to not only reflect AD-related neuropathology but also cognitive impairment. In this review, we summarize the applications and key findings of MRI techniques in the context of both AD subjects and AD transgenic mouse models. Furthermore, the possible mechanisms of relaxation time alterations in AD will be discussed. Future studies could focus on relaxation time alterations in the early stage of AD, and longitudinal studies are needed to further explore relaxation time alterations during disease progression.The magnetic resonance imaging (MRI) relaxation time constants, T1 and T2, are sensitive to changes in brain tissue microstructure integrity. Quantitative T1 and T2 relaxation times have been proposed to serve as non-invasive biomarkers of Alzheimer's disease (AD), in which alterations are believed to not only reflect AD-related neuropathology but also cognitive impairment. In this review, we summarize the applications and key findings of MRI techniques in the context of both AD subjects and AD transgenic mouse models. Furthermore, the possible mechanisms of relaxation time alterations in AD will be discussed. Future studies could focus on relaxation time alterations in the early stage of AD, and longitudinal studies are needed to further explore relaxation time alterations during disease progression.
The magnetic resonance imaging (MRI) relaxation time constants, T1 and T2, are sensitive to changes in brain tissue microstructure integrity. Quantitative T1 and T2 relaxation times have been proposed to serve as non-invasive biomarkers of Alzheimer's disease (AD), in which alterations are believed to not only reflect AD-related neuropathology but also cognitive impairment. In this review, we summarize the applications and key findings of MRI techniques in the context of both AD subjects and AD transgenic mouse models. Furthermore, the possible mechanisms of relaxation time alterations in AD will be discussed. Future studies could focus on relaxation time alterations in the early stage of AD, and longitudinal studies are needed to further explore relaxation time alterations during disease progression.
Author Tang, Xiang
Fang, Qi
Cai, Xiu-Ying
Cai, Feng
Ding, Dong-Xue
Zhang, Lu-Lu
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  givenname: Feng
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  surname: Ding
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  givenname: Lu-Lu
  surname: Zhang
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  organization: Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29738781$$D View this record in MEDLINE/PubMed
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Keywords Biomarker
Magnetic resonance imaging
T1 relaxation time
Alzheimer’s disease
T2 relaxation time
Language English
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Snippet •T1 and T2 relaxation times in brain tissue.•Applications of T1 and T2 relaxation time in AD (AD patients and mouse models).•Possible mechanisms of T1 and T2...
The magnetic resonance imaging (MRI) relaxation time constants, T1 and T2, are sensitive to changes in brain tissue microstructure integrity. Quantitative T1...
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StartPage 176
SubjectTerms Alzheimer’s disease
Biomarker
Magnetic resonance imaging
T1 relaxation time
T2 relaxation time
Title Magnetic resonance imaging relaxation time in Alzheimer’s disease
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0361923018300388
https://dx.doi.org/10.1016/j.brainresbull.2018.05.004
https://www.ncbi.nlm.nih.gov/pubmed/29738781
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