Metabolism and Excretion of the Once-Daily Human Glucagon-Like Peptide-1 Analog Liraglutide in Healthy Male Subjects and Its In Vitro Degradation by Dipeptidyl Peptidase IV and Neutral Endopeptidase - Malm-Erjefält, Monika; Bjørnsdottir, Inga; Vanggaard, Jan; Helleberg, Hans; Larsen, Uffe; Oosterhuis, Berend; van Lier, Jan Jaap; Zdravkovic, Milan; Olsen, Anette K. (Drug metabolism and disposition, 2010)
Keywords: Biological and medical sciences; Chromatography, High Pressure Liquid; Dipeptidyl Peptidase 4 - chemistry; Dipeptidyl Peptidase 4 - metabolism; Enzyme-Linked Immunosorbent Assay; Feces - chemistry; General pharmacology; Glucagon-Like Peptide 1 - analogs & derivatives; Glucagon-Like Peptide 1 - blood; Glucagon-Like Peptide 1 - chemistry; Glucagon-Like Peptide 1 - metabolism; Glucagon-Like Peptide 1 - pharmacokinetics; Glucagon-Like Peptide 1 - urine; Humans; Hypoglycemic Agents - blood; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacokinetics; Hypoglycemic Agents - urine; Inactivation, Metabolic; Injections, Subcutaneous; Liraglutide; Male; Medical sciences; Metabolic Clearance Rate; Middle Aged; Neprilysin - chemistry; Neprilysin - metabolism; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Cmax; GLP-1; DPP-IV; MS; MS/MS; AUC; t1/2; LC; NEP; LSC; PRA; HPLC; ELISA; Dipeptidyl-peptidase IV; Human; Incretin; Excretion; Healthy subject; Enzyme; Metalloendopeptidases; Metabolism; In vitro; Glucagon like peptide 1; Degradation; Peptidases; Hypoglycemic agent; Gastrointestinal hormone; Analog; Hydrolases; Single daily dose; Neprilysin; Pharmacokinetics; Daily dose; Liraglutide