Complexity of Damage-Associated Molecular Pattern Molecule Expression Profile in Porcine Brain Affected by Ischemic Stroke

• Published in: International journal of molecular sciences Vol. 26; no. 8; p. 3702
• Main Authors: Golubczyk, Dominika, Mowinska, Aleksandra, Holak, Piotr, Walczak, Piotr, Janowski, Miroslaw, Malysz-Cymborska, Izabela
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.04.2025; MDPI
• Subjects: Alarmins - genetics; Alarmins - metabolism; Analysis; Animals; Binding proteins; Brain - metabolism; Brain - pathology; Brain Ischemia - metabolism; Brain research; Cytokines; Disease Models, Animal; Endothelial growth factors; Gene expression; Heat shock proteins; Interleukins; Ischemia; Ischemic Stroke - genetics; Ischemic Stroke - metabolism; Ischemic Stroke - pathology; Molecules; Nervous system diseases; Protein binding; Proteins; Stroke (Disease); Swine; Tissues; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; Poland; California; United States; Germany; animal model; brain; stroke; DAMPs; pig

Studies using large animal models are essential for better understanding the molecular processes underlying neurological diseases, including ischemic stroke, and serve as a robust foundation for evaluating potential therapies. To better understand the complex role of damage-associated molecular patt...