Gene Co-Expression Analysis of Multiple Brain Tissues Reveals Correlation of FAM222A Expression with Multiple Alzheimer’s Disease-Related Genes

• Published in: Journal of Alzheimer's disease Vol. 99; no. s2; pp. S249 - S263
• Main Authors: Liang, Jingjing, LaFleur, Bonnie, Hussainy, Sadiya, Perry, George
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 07.05.2024
• Subjects: Aged; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Brain - metabolism; Brain - pathology; Female; Gene Expression Profiling; Genome-Wide Association Study; Humans; Male; neurodegeneration; transcriptomics; FAM222A; Alzheimer’s disease; gene co-expression network analysis

Background: Alzheimer’s disease (AD) is the most common form of dementia in the elderly marked by central nervous system (CNS) neuronal loss and amyloid plaques. FAM222A, encoding an amyloid plaque core protein, is an AD brain atrophy susceptibility gene that mediates amyloid-β aggregation. However,...