Mechanistic Modeling of Placental Drug Transfer in Humans: How Do Differences in Maternal/Fetal Fraction of Unbound Drug and Placental Influx/Efflux Transfer Rates Affect Fetal Pharmacokinetics?

• Published in: Frontiers in pediatrics Vol. 9; p. 723006
• Main Authors: Liu, Xiaomei I., Green, Dionna J., van den Anker, John N., Rakhmanina, Natella Y., Ahmadzia, Homa K., Momper, Jeremiah D., Park, Kyunghun, Burckart, Gilbert J., Dallmann, André
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 18.10.2021
• Subjects: maternal-fetal; mechanistic modeling; Pediatrics; physiologically based pharmacokinetics (PBPK); placental drug transfer; pregnancy

Background: While physiologically based pharmacokinetic (PBPK) models generally predict pharmacokinetics in pregnant women successfully, the confidence in predicting fetal pharmacokinetics is limited because many parameters affecting placental drug transfer have not been mechanistically accounted fo...