Human Immunodeficiency Virus Type 1 V1-to-V5 Envelope Variants from the Chronic Phase of Infection Use CCR5 and Fuse More Efficiently than Those from Early after Infection

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Published inJournal of Virology Vol. 83; no. 19; pp. 9694 - 9708
Main Authors Etemad, Behzad, Fellows, Angela, Kwambana, Brenda, Kamat, Anupa, Feng, Yang, Lee, Sandra, Sagar, Manish
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.10.2009
American Society for Microbiology (ASM)
Subjects
Biological and medical sciences
CD4 Antigens - metabolism
Cell Line
Fundamental and applied biological sciences. Psychology
Genotype
HIV Infections - metabolism
HIV Infections - virology
HIV-1 - metabolism
Humans
Inhibitory Concentration 50
Kinetics
Macrophages - virology
Microbiology
Miscellaneous
Models, Biological
Monocytes - virology
Polymerase Chain Reaction
Protein Structure, Tertiary
Receptors, CCR5 - metabolism
Viral Envelope Proteins - metabolism
Virology
Virus-Cell Interactions
Virus
Infection
CCR5 chemokine receptor
Immunopathology
Chronic
HIV-1 virus
Viral disease
Retroviridae
AIDS
Human immunodeficiency virus
Immune deficiency
Lentivirus
Online AccessGet full text
ISSN0022-538X
1098-5514
1098-5514
DOI10.1128/JVI.00925-09

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Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList Human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein modifications over the course of infection have been associated with coreceptor switching and antibody neutralization resistance, but the effect of the changes on replication and host cell receptor usage remains unclear. To examine this question, unique early- and chronic-stage infection envelope V1-toV5 (V1-V5) segments from eight HIV-1 subtype A-infected subjects were incorporated into an isogenic background to construct replication-competent recombinant viruses. In all subjects, viruses with chronic-infection V1-V5 segments showed greater replication capacity than those with early-infection V1-V5 domains in cell lines with high levels of both the CD4 and the CCR5 receptors. Viruses with chronic-infection V1-V5s demonstrated a significantly increased ability to replicate in cells with low CCR5 receptor levels and greater resistance to CCR5 receptor and fusion inhibitors compared to those with early-infection V1-V5 segments. These properties were associated with sequence changes in the envelope V1-V3 segments. Viruses with the envelope segments from the two infection time points showed no significant difference in their ability to infect cells with low CD4 receptor densities, in their sensitivity to soluble CD4, or in their replication capacity in monocyte-derived macrophages. Our results suggest that envelope changes, primarily in the V1-V3 domains, increase both the ability to use the CCR5 receptor and fusion kinetics. Thus, envelope modifications over time within a host potentially enhance replication capacity.
Human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein modifications over the course of infection have been associated with coreceptor switching and antibody neutralization resistance, but the effect of the changes on replication and host cell receptor usage remains unclear. To examine this question, unique early- and chronic-stage infection envelope V1-to V5 (V1-V5) segments from eight HIV-1 subtype A-infected subjects were incorporated into an isogenic background to construct replication-competent recombinant viruses. In all subjects, viruses with chronic-infection V1-V5 segments showed greater replication capacity than those with early-infection V1-V5 domains in cell lines with high levels of both the CD4 and the CCR5 receptors. Viruses with chronic-infection V1-V5s demonstrated a significantly increased ability to replicate in cells with low CCR5 receptor levels and greater resistance to CCR5 receptor and fusion inhibitors compared to those with early-infection V1-V5 segments. These properties were associated with sequence changes in the envelope V1-V3 segments. Viruses with the envelope segments from the two infection time points showed no significant difference in their ability to infect cells with low CD4 receptor densities, in their sensitivity to soluble CD4, or in their replication capacity in monocyte-derived macrophages. Our results suggest that envelope changes, primarily in the V1-V3 domains, increase both the ability to use the CCR5 receptor and fusion kinetics. Thus, envelope modifications over time within a host potentially enhance replication capacity.Human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein modifications over the course of infection have been associated with coreceptor switching and antibody neutralization resistance, but the effect of the changes on replication and host cell receptor usage remains unclear. To examine this question, unique early- and chronic-stage infection envelope V1-to V5 (V1-V5) segments from eight HIV-1 subtype A-infected subjects were incorporated into an isogenic background to construct replication-competent recombinant viruses. In all subjects, viruses with chronic-infection V1-V5 segments showed greater replication capacity than those with early-infection V1-V5 domains in cell lines with high levels of both the CD4 and the CCR5 receptors. Viruses with chronic-infection V1-V5s demonstrated a significantly increased ability to replicate in cells with low CCR5 receptor levels and greater resistance to CCR5 receptor and fusion inhibitors compared to those with early-infection V1-V5 segments. These properties were associated with sequence changes in the envelope V1-V3 segments. Viruses with the envelope segments from the two infection time points showed no significant difference in their ability to infect cells with low CD4 receptor densities, in their sensitivity to soluble CD4, or in their replication capacity in monocyte-derived macrophages. Our results suggest that envelope changes, primarily in the V1-V3 domains, increase both the ability to use the CCR5 receptor and fusion kinetics. Thus, envelope modifications over time within a host potentially enhance replication capacity.
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
Human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein modifications over the course of infection have been associated with coreceptor switching and antibody neutralization resistance, but the effect of the changes on replication and host cell receptor usage remains unclear. To examine this question, unique early- and chronic-stage infection envelope V1-to V5 (V1-V5) segments from eight HIV-1 subtype A-infected subjects were incorporated into an isogenic background to construct replication-competent recombinant viruses. In all subjects, viruses with chronic-infection V1-V5 segments showed greater replication capacity than those with early-infection V1-V5 domains in cell lines with high levels of both the CD4 and the CCR5 receptors. Viruses with chronic-infection V1-V5s demonstrated a significantly increased ability to replicate in cells with low CCR5 receptor levels and greater resistance to CCR5 receptor and fusion inhibitors compared to those with early-infection V1-V5 segments. These properties were associated with sequence changes in the envelope V1-V3 segments. Viruses with the envelope segments from the two infection time points showed no significant difference in their ability to infect cells with low CD4 receptor densities, in their sensitivity to soluble CD4, or in their replication capacity in monocyte-derived macrophages. Our results suggest that envelope changes, primarily in the V1-V3 domains, increase both the ability to use the CCR5 receptor and fusion kinetics. Thus, envelope modifications over time within a host potentially enhance replication capacity.
Author Behzad Etemad
Brenda Kwambana
Sandra Lee
Anupa Kamat
Yang Feng
Angela Fellows
Manish Sagar
AuthorAffiliation Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, 1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health, Boston, Massachusetts 02115 2
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Cites_doi 10.1089/088922299309955
10.1128/JVI.02328-05
10.1128/jvi.66.4.2232-2239.1992
10.1016/j.virol.2006.11.004
10.1099/vir.0.81111-0
10.1038/373117a0
10.1099/0022-1317-83-8-1809
10.1073/pnas.252469399
10.1086/374650
10.1128/jvi.64.12.5701-5707.1990
10.1038/31405
10.1006/viro.1997.8673
10.1128/JVI.79.14.9006-9018.2005
10.1128/JVI.79.11.7121-7134.2005
10.1128/JVI.78.10.5476-5485.2004
10.1086/377105
10.1128/JVI.72.1.209-217.1998
10.1128/JVI.02006-06
10.1186/1742-4690-5-5
10.1128/JVI.73.3.2343-2349.1999
10.1038/nature01470
10.1128/JVI.77.2.1021-1038.2003
10.1590/S0074-02762000000200014
10.1128/JVI.02739-06
10.1089/aid.1998.14.129
10.1128/JVI.72.6.5035-5045.1998
10.1128/JVI.74.18.8358-8367.2000
10.1128/JVI.76.12.6277-6292.2002
10.1126/science.3012778
10.1126/science.1059128
10.1128/JVI.00141-06
10.1073/pnas.93.26.15382
10.1128/JVI.72.4.2855-2864.1998
10.1128/jvi.65.8.3973-3985.1991
10.1089/088922202753747914
10.1128/jcm.33.4.906-911.1995
10.1128/JVI.73.12.9741-9755.1999
10.1126/science.1099288
10.1128/JVI.00444-08
10.1126/science.7824947
10.1016/0042-6822(91)90537-L
10.1089/aid.1996.12.877
10.1016/S0166-0934(03)00166-6
10.1128/JVI.77.23.12921-12926.2003
10.1128/JVI.73.7.5255-5264.1999
10.1146/annurev.immunol.24.021605.090557
10.1086/514219
10.1128/JVI.78.21.11807-11815.2004
10.1073/pnas.0630530100
10.1038/nm833
10.1126/science.271.5255.1582
10.1128/JVI.79.17.11161-11169.2005
10.1128/jvi.71.10.7719-7727.1997
10.1016/0092-8674(86)90778-6
10.1089/aid.2006.22.430
10.1038/373123a0
10.1128/JVI.77.16.9069-9073.2003
10.1126/science.276.5309.51
10.1128/JVI.73.7.5294-5300.1999
10.1089/088922202753519133
10.1128/JVI.73.12.10489-10502.1999
10.1073/pnas.96.10.5698
10.1084/jem.20040874
10.1128/jvi.66.5.3183-3187.1992
10.1128/AAC.47.2.509-517.2003
10.1128/AAC.46.6.1896-1905.2002
10.1128/JVI.78.4.1962-1970.2004
10.1073/pnas.012519099
10.1128/jvi.66.11.6777-6780.1992
10.1128/jvi.64.11.5270-5276.1990
10.1126/science.280.5371.1949
10.1016/S0092-8674(01)00234-3
10.1038/8414
10.1093/hmg/8.10.1939
10.1128/JVI.79.13.8454-8469.2005
10.1128/JVI.00218-07
10.1128/JVI.77.24.13376-13388.2003
10.1084/jem.20041196
10.1086/315315
10.1128/jvi.64.10.4735-4742.1990
10.1073/pnas.0605513103
10.1128/JVI.79.7.4347-4356.2005
10.1016/j.virol.2005.04.034
10.1097/QAI.0b013e3180385aa0
10.1016/S0002-9440(10)65591-5
10.1073/pnas.0504658102
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Keywords Virus
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CCR5 chemokine receptor
Immunopathology
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HIV-1 virus
Viral disease
Retroviridae
AIDS
Human immunodeficiency virus
Immune deficiency
Lentivirus
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Corresponding author. Mailing address: Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Room 447, Cambridge, MA 02139. Phone: (617) 768-8372. Fax: (617) 768-8738. E-mail: msagar@partners.org
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References e_1_3_2_26_2
e_1_3_2_49_2
e_1_3_2_28_2
e_1_3_2_41_2
e_1_3_2_64_2
e_1_3_2_87_2
e_1_3_2_20_2
e_1_3_2_43_2
e_1_3_2_62_2
e_1_3_2_85_2
e_1_3_2_22_2
e_1_3_2_45_2
e_1_3_2_68_2
e_1_3_2_24_2
e_1_3_2_47_2
e_1_3_2_66_2
e_1_3_2_89_2
e_1_3_2_60_2
e_1_3_2_83_2
e_1_3_2_81_2
e_1_3_2_9_2
e_1_3_2_16_2
e_1_3_2_37_2
e_1_3_2_7_2
e_1_3_2_18_2
e_1_3_2_39_2
e_1_3_2_54_2
e_1_3_2_75_2
e_1_3_2_10_2
e_1_3_2_31_2
e_1_3_2_52_2
e_1_3_2_73_2
e_1_3_2_5_2
e_1_3_2_12_2
e_1_3_2_33_2
e_1_3_2_58_2
e_1_3_2_79_2
e_1_3_2_3_2
e_1_3_2_14_2
e_1_3_2_35_2
e_1_3_2_56_2
e_1_3_2_77_2
e_1_3_2_50_2
e_1_3_2_71_2
e_1_3_2_27_2
e_1_3_2_48_2
e_1_3_2_29_2
e_1_3_2_40_2
e_1_3_2_65_2
e_1_3_2_86_2
e_1_3_2_21_2
e_1_3_2_42_2
e_1_3_2_63_2
e_1_3_2_84_2
e_1_3_2_23_2
e_1_3_2_44_2
e_1_3_2_69_2
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e_1_3_2_61_2
e_1_3_2_82_2
e_1_3_2_80_2
e_1_3_2_15_2
e_1_3_2_38_2
e_1_3_2_8_2
e_1_3_2_17_2
e_1_3_2_59_2
e_1_3_2_6_2
e_1_3_2_19_2
e_1_3_2_30_2
e_1_3_2_53_2
e_1_3_2_76_2
e_1_3_2_32_2
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e_1_3_2_57_2
e_1_3_2_4_2
e_1_3_2_13_2
e_1_3_2_36_2
e_1_3_2_55_2
e_1_3_2_78_2
e_1_3_2_2_2
e_1_3_2_72_2
e_1_3_2_70_2
16973562 - J Virol. 2006 Oct;80(19):9586-98
17182681 - J Virol. 2007 Mar;81(5):2359-71
10559367 - J Virol. 1999 Dec;73(12):10489-502
17522224 - J Virol. 2007 Aug;81(15):8258-69
16103167 - J Virol. 2005 Sep;79(17):11161-9
9122710 - Science. 1997 Apr 4;276(5309):51-2
10364271 - J Virol. 1999 Jul;73(7):5255-64
15479822 - J Virol. 2004 Nov;78(21):11807-15
1683726 - Virology. 1991 Dec;185(2):661-72
7816094 - Nature. 1995 Jan 12;373(6510):123-6
9462923 - AIDS Res Hum Retroviruses. 1998 Jan 20;14(2):129-38
15994794 - J Virol. 2005 Jul;79(14):9006-18
8986820 - Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15382-7
10318947 - Proc Natl Acad Sci U S A. 1999 May 11;96(10):5698-703
16339909 - Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18514-9
12644702 - Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4144-9
12717620 - J Infect Dis. 2003 May 1;187(9):1397-403
7824947 - Science. 1995 Jan 27;267(5197):483-9
10364275 - J Virol. 1999 Jul;73(7):5294-300
10559284 - J Virol. 1999 Dec;73(12):9741-55
1548759 - J Virol. 1992 Apr;66(4):2232-9
15486300 - Science. 2004 Oct 15;306(5695):485-7
18205925 - Retrovirology. 2008;5:5
15113926 - J Virol. 2004 May;78(10):5476-85
12964118 - J Infect Dis. 2003 Sep 15;188(6):864-72
9268166 - Virology. 1997 Aug 4;234(2):340-8
2243375 - J Virol. 1990 Dec;64(12):5701-7
8798972 - AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):877-83
16551265 - Annu Rev Immunol. 2006;24:739-69
12885922 - J Virol. 2003 Aug;77(16):9069-73
10733742 - Mem Inst Oswaldo Cruz. 2000 Mar-Apr;95(2):221-3
18495779 - J Virol. 2008 Aug;82(16):8210-4
12019106 - Antimicrob Agents Chemother. 2002 Jun;46(6):1896-905
17310935 - J Acquir Immune Defic Syndr. 2007 May 1;45(1):28-33
12579198 - Nat Med. 2003 Mar;9(3):343-6
16775320 - J Virol. 2006 Jul;80(13):6324-32
14645592 - J Virol. 2003 Dec;77(24):13376-88
1404617 - J Virol. 1992 Nov;66(11):6777-80
10555107 - AIDS Res Hum Retroviruses. 1999 Nov 1;15(16):1441-52
10720514 - J Infect Dis. 2000 Mar;181(3):927-32
14610215 - J Virol. 2003 Dec;77(23):12921-6
17507467 - J Virol. 2007 Aug;81(15):7885-93
9632396 - Science. 1998 Jun 19;280(5371):1949-53
10469847 - Hum Mol Genet. 1999;8(10):1939-45
17015824 - Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15160-5
9708808 - Am J Pathol. 1998 Aug;153(2):481-90
15956589 - J Virol. 2005 Jul;79(13):8454-69
11239404 - Cell. 2001 Feb 23;104(4):469-72
11782552 - Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):395-400
9641677 - Nature. 1998 Jun 18;393(6686):648-59
11897037 - AIDS Res Hum Retroviruses. 2002 Mar 20;18(5):353-62
1830110 - J Virol. 1991 Aug;65(8):3973-85
9525605 - J Virol. 1998 Apr;72(4):2855-64
12646921 - Nature. 2003 Mar 20;422(6929):307-12
16186242 - J Gen Virol. 2005 Oct;86(Pt 10):2859-69
7529365 - Nature. 1995 Jan 12;373(6510):117-22
10954535 - J Virol. 2000 Sep;74(18):8358-67
2423250 - Cell. 1986 Jun 6;45(5):637-48
9498438 - J Infect Dis. 1998 Mar;177(3):600-10
3012778 - Science. 1986 Jun 20;232(4757):1548-53
9420217 - J Virol. 1998 Jan;72(1):209-17
12880926 - J Virol Methods. 2003 Aug;111(2):111-20
12124446 - J Gen Virol. 2002 Aug;83(Pt 8):1809-29
15890952 - J Virol. 2005 Jun;79(11):7121-34
12543651 - Antimicrob Agents Chemother. 2003 Feb;47(2):509-17
15365095 - J Exp Med. 2004 Sep 20;200(6):761-70
9573273 - J Virol. 1998 Jun;72(6):5035-45
12444251 - Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16249-54
14747561 - J Virol. 2004 Feb;78(4):1962-70
2398528 - J Virol. 1990 Oct;64(10):4735-42
1560543 - J Virol. 1992 May;66(5):3183-7
2214018 - J Virol. 1990 Nov;64(11):5270-6
17166540 - Virology. 2007 Apr 25;361(1):212-28
12036486 - AIDS Res Hum Retroviruses. 2002 May 20;18(8):567-76
10229230 - Nat Med. 1999 May;5(5):535-41
8599114 - Science. 1996 Mar 15;271(5255):1582-6
15916792 - Virology. 2005 Jul 5;337(2):384-98
11352065 - Science. 2001 May 11;292(5519):1106-9
7790458 - J Clin Microbiol. 1995 Apr;33(4):906-11
16706620 - AIDS Res Hum Retroviruses. 2006 May;22(5):430-7
15365096 - J Exp Med. 2004 Sep 20;200(6):749-59
9311856 - J Virol. 1997 Oct;71(10):7719-27
9971817 - J Virol. 1999 Mar;73(3):2343-9
15767435 - J Virol. 2005 Apr;79(7):4347-56
12021361 - J Virol. 2002 Jun;76(12):6277-92
12502818 - J Virol. 2003 Jan;77(2):1021-38
References_xml – ident: e_1_3_2_51_2
  doi: 10.1089/088922299309955
– ident: e_1_3_2_61_2
  doi: 10.1128/JVI.02328-05
– ident: e_1_3_2_33_2
  doi: 10.1128/jvi.66.4.2232-2239.1992
– ident: e_1_3_2_65_2
  doi: 10.1016/j.virol.2006.11.004
– ident: e_1_3_2_69_2
  doi: 10.1099/vir.0.81111-0
– ident: e_1_3_2_87_2
  doi: 10.1038/373117a0
– ident: e_1_3_2_12_2
  doi: 10.1099/0022-1317-83-8-1809
– ident: e_1_3_2_67_2
  doi: 10.1073/pnas.252469399
– ident: e_1_3_2_35_2
  doi: 10.1086/374650
– ident: e_1_3_2_50_2
  doi: 10.1128/jvi.64.12.5701-5707.1990
– ident: e_1_3_2_36_2
  doi: 10.1038/31405
– ident: e_1_3_2_2_2
  doi: 10.1006/viro.1997.8673
– ident: e_1_3_2_81_2
  doi: 10.1128/JVI.79.14.9006-9018.2005
– ident: e_1_3_2_45_2
  doi: 10.1128/JVI.79.11.7121-7134.2005
– ident: e_1_3_2_68_2
  doi: 10.1128/JVI.78.10.5476-5485.2004
– ident: e_1_3_2_34_2
  doi: 10.1086/377105
– ident: e_1_3_2_73_2
  doi: 10.1128/JVI.72.1.209-217.1998
– ident: e_1_3_2_88_2
  doi: 10.1128/JVI.02006-06
– ident: e_1_3_2_60_2
  doi: 10.1186/1742-4690-5-5
– ident: e_1_3_2_49_2
  doi: 10.1128/JVI.73.3.2343-2349.1999
– ident: e_1_3_2_86_2
  doi: 10.1038/nature01470
– ident: e_1_3_2_4_2
  doi: 10.1128/JVI.77.2.1021-1038.2003
– ident: e_1_3_2_15_2
  doi: 10.1590/S0074-02762000000200014
– ident: e_1_3_2_14_2
– ident: e_1_3_2_41_2
  doi: 10.1128/JVI.02739-06
– ident: e_1_3_2_18_2
  doi: 10.1089/aid.1998.14.129
– ident: e_1_3_2_89_2
  doi: 10.1128/JVI.72.6.5035-5045.1998
– ident: e_1_3_2_17_2
  doi: 10.1128/JVI.74.18.8358-8367.2000
– ident: e_1_3_2_23_2
  doi: 10.1128/JVI.76.12.6277-6292.2002
– ident: e_1_3_2_25_2
  doi: 10.1126/science.3012778
– ident: e_1_3_2_52_2
  doi: 10.1126/science.1059128
– ident: e_1_3_2_77_2
  doi: 10.1128/JVI.00141-06
– ident: e_1_3_2_28_2
  doi: 10.1073/pnas.93.26.15382
– ident: e_1_3_2_63_2
  doi: 10.1128/JVI.72.4.2855-2864.1998
– ident: e_1_3_2_40_2
  doi: 10.1128/jvi.65.8.3973-3985.1991
– ident: e_1_3_2_42_2
  doi: 10.1089/088922202753747914
– ident: e_1_3_2_20_2
  doi: 10.1128/jcm.33.4.906-911.1995
– ident: e_1_3_2_39_2
  doi: 10.1128/JVI.73.12.9741-9755.1999
– ident: e_1_3_2_37_2
  doi: 10.1126/science.1099288
– ident: e_1_3_2_82_2
  doi: 10.1128/JVI.00444-08
– ident: e_1_3_2_58_2
– ident: e_1_3_2_13_2
  doi: 10.1126/science.7824947
– ident: e_1_3_2_57_2
  doi: 10.1016/0042-6822(91)90537-L
– ident: e_1_3_2_38_2
  doi: 10.1089/aid.1996.12.877
– ident: e_1_3_2_44_2
  doi: 10.1016/S0166-0934(03)00166-6
– ident: e_1_3_2_76_2
  doi: 10.1128/JVI.77.23.12921-12926.2003
– ident: e_1_3_2_64_2
  doi: 10.1128/JVI.73.7.5255-5264.1999
– ident: e_1_3_2_54_2
  doi: 10.1146/annurev.immunol.24.021605.090557
– ident: e_1_3_2_5_2
  doi: 10.1086/514219
– ident: e_1_3_2_31_2
  doi: 10.1128/JVI.78.21.11807-11815.2004
– ident: e_1_3_2_71_2
  doi: 10.1073/pnas.0630530100
– ident: e_1_3_2_84_2
  doi: 10.1038/nm833
– ident: e_1_3_2_59_2
  doi: 10.1126/science.271.5255.1582
– ident: e_1_3_2_47_2
  doi: 10.1128/JVI.79.17.11161-11169.2005
– ident: e_1_3_2_9_2
  doi: 10.1128/jvi.71.10.7719-7727.1997
– ident: e_1_3_2_79_2
  doi: 10.1016/0092-8674(86)90778-6
– ident: e_1_3_2_75_2
  doi: 10.1089/aid.2006.22.430
– ident: e_1_3_2_26_2
  doi: 10.1038/373123a0
– ident: e_1_3_2_66_2
  doi: 10.1128/JVI.77.16.9069-9073.2003
– ident: e_1_3_2_48_2
  doi: 10.1126/science.276.5309.51
– ident: e_1_3_2_10_2
  doi: 10.1128/JVI.73.7.5294-5300.1999
– ident: e_1_3_2_83_2
  doi: 10.1089/088922202753519133
– ident: e_1_3_2_78_2
  doi: 10.1128/JVI.73.12.10489-10502.1999
– ident: e_1_3_2_3_2
  doi: 10.1073/pnas.96.10.5698
– ident: e_1_3_2_6_2
  doi: 10.1084/jem.20040874
– ident: e_1_3_2_21_2
  doi: 10.1128/jvi.66.5.3183-3187.1992
– ident: e_1_3_2_55_2
  doi: 10.1128/AAC.47.2.509-517.2003
– ident: e_1_3_2_85_2
  doi: 10.1128/AAC.46.6.1896-1905.2002
– ident: e_1_3_2_11_2
  doi: 10.1128/JVI.78.4.1962-1970.2004
– ident: e_1_3_2_80_2
  doi: 10.1073/pnas.012519099
– ident: e_1_3_2_16_2
  doi: 10.1128/jvi.66.11.6777-6780.1992
– ident: e_1_3_2_53_2
  doi: 10.1128/jvi.64.11.5270-5276.1990
– ident: e_1_3_2_72_2
  doi: 10.1126/science.280.5371.1949
– ident: e_1_3_2_43_2
  doi: 10.1016/S0092-8674(01)00234-3
– ident: e_1_3_2_32_2
  doi: 10.1038/8414
– ident: e_1_3_2_8_2
  doi: 10.1093/hmg/8.10.1939
– ident: e_1_3_2_74_2
  doi: 10.1128/JVI.79.13.8454-8469.2005
– ident: e_1_3_2_27_2
  doi: 10.1128/JVI.00218-07
– ident: e_1_3_2_29_2
  doi: 10.1128/JVI.77.24.13376-13388.2003
– ident: e_1_3_2_46_2
  doi: 10.1084/jem.20041196
– ident: e_1_3_2_70_2
  doi: 10.1086/315315
– ident: e_1_3_2_7_2
  doi: 10.1128/jvi.64.10.4735-4742.1990
– ident: e_1_3_2_19_2
  doi: 10.1073/pnas.0605513103
– ident: e_1_3_2_62_2
  doi: 10.1128/JVI.79.7.4347-4356.2005
– ident: e_1_3_2_24_2
  doi: 10.1016/j.virol.2005.04.034
– ident: e_1_3_2_30_2
  doi: 10.1097/QAI.0b013e3180385aa0
– ident: e_1_3_2_56_2
  doi: 10.1016/S0002-9440(10)65591-5
– ident: e_1_3_2_22_2
  doi: 10.1073/pnas.0504658102
– reference: 12019106 - Antimicrob Agents Chemother. 2002 Jun;46(6):1896-905
– reference: 12036486 - AIDS Res Hum Retroviruses. 2002 May 20;18(8):567-76
– reference: 17166540 - Virology. 2007 Apr 25;361(1):212-28
– reference: 14747561 - J Virol. 2004 Feb;78(4):1962-70
– reference: 9498438 - J Infect Dis. 1998 Mar;177(3):600-10
– reference: 16551265 - Annu Rev Immunol. 2006;24:739-69
– reference: 10720514 - J Infect Dis. 2000 Mar;181(3):927-32
– reference: 14610215 - J Virol. 2003 Dec;77(23):12921-6
– reference: 12880926 - J Virol Methods. 2003 Aug;111(2):111-20
– reference: 15365096 - J Exp Med. 2004 Sep 20;200(6):749-59
– reference: 12579198 - Nat Med. 2003 Mar;9(3):343-6
– reference: 17182681 - J Virol. 2007 Mar;81(5):2359-71
– reference: 10229230 - Nat Med. 1999 May;5(5):535-41
– reference: 11352065 - Science. 2001 May 11;292(5519):1106-9
– reference: 12124446 - J Gen Virol. 2002 Aug;83(Pt 8):1809-29
– reference: 1683726 - Virology. 1991 Dec;185(2):661-72
– reference: 9420217 - J Virol. 1998 Jan;72(1):209-17
– reference: 17015824 - Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15160-5
– reference: 12964118 - J Infect Dis. 2003 Sep 15;188(6):864-72
– reference: 10469847 - Hum Mol Genet. 1999;8(10):1939-45
– reference: 10555107 - AIDS Res Hum Retroviruses. 1999 Nov 1;15(16):1441-52
– reference: 1548759 - J Virol. 1992 Apr;66(4):2232-9
– reference: 9268166 - Virology. 1997 Aug 4;234(2):340-8
– reference: 18495779 - J Virol. 2008 Aug;82(16):8210-4
– reference: 7824947 - Science. 1995 Jan 27;267(5197):483-9
– reference: 2214018 - J Virol. 1990 Nov;64(11):5270-6
– reference: 16103167 - J Virol. 2005 Sep;79(17):11161-9
– reference: 12444251 - Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16249-54
– reference: 15890952 - J Virol. 2005 Jun;79(11):7121-34
– reference: 15916792 - Virology. 2005 Jul 5;337(2):384-98
– reference: 12885922 - J Virol. 2003 Aug;77(16):9069-73
– reference: 8986820 - Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15382-7
– reference: 1560543 - J Virol. 1992 May;66(5):3183-7
– reference: 3012778 - Science. 1986 Jun 20;232(4757):1548-53
– reference: 16775320 - J Virol. 2006 Jul;80(13):6324-32
– reference: 2423250 - Cell. 1986 Jun 6;45(5):637-48
– reference: 9311856 - J Virol. 1997 Oct;71(10):7719-27
– reference: 18205925 - Retrovirology. 2008;5:5
– reference: 1830110 - J Virol. 1991 Aug;65(8):3973-85
– reference: 12502818 - J Virol. 2003 Jan;77(2):1021-38
– reference: 16186242 - J Gen Virol. 2005 Oct;86(Pt 10):2859-69
– reference: 1404617 - J Virol. 1992 Nov;66(11):6777-80
– reference: 9122710 - Science. 1997 Apr 4;276(5309):51-2
– reference: 7790458 - J Clin Microbiol. 1995 Apr;33(4):906-11
– reference: 16706620 - AIDS Res Hum Retroviruses. 2006 May;22(5):430-7
– reference: 2243375 - J Virol. 1990 Dec;64(12):5701-7
– reference: 9708808 - Am J Pathol. 1998 Aug;153(2):481-90
– reference: 17522224 - J Virol. 2007 Aug;81(15):8258-69
– reference: 9525605 - J Virol. 1998 Apr;72(4):2855-64
– reference: 8599114 - Science. 1996 Mar 15;271(5255):1582-6
– reference: 10559367 - J Virol. 1999 Dec;73(12):10489-502
– reference: 7529365 - Nature. 1995 Jan 12;373(6510):117-22
– reference: 11239404 - Cell. 2001 Feb 23;104(4):469-72
– reference: 10364271 - J Virol. 1999 Jul;73(7):5255-64
– reference: 10364275 - J Virol. 1999 Jul;73(7):5294-300
– reference: 10733742 - Mem Inst Oswaldo Cruz. 2000 Mar-Apr;95(2):221-3
– reference: 12021361 - J Virol. 2002 Jun;76(12):6277-92
– reference: 12644702 - Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4144-9
– reference: 15113926 - J Virol. 2004 May;78(10):5476-85
– reference: 15956589 - J Virol. 2005 Jul;79(13):8454-69
– reference: 11782552 - Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):395-400
– reference: 15479822 - J Virol. 2004 Nov;78(21):11807-15
– reference: 17507467 - J Virol. 2007 Aug;81(15):7885-93
– reference: 12646921 - Nature. 2003 Mar 20;422(6929):307-12
– reference: 15486300 - Science. 2004 Oct 15;306(5695):485-7
– reference: 9632396 - Science. 1998 Jun 19;280(5371):1949-53
– reference: 2398528 - J Virol. 1990 Oct;64(10):4735-42
– reference: 15767435 - J Virol. 2005 Apr;79(7):4347-56
– reference: 11897037 - AIDS Res Hum Retroviruses. 2002 Mar 20;18(5):353-62
– reference: 12717620 - J Infect Dis. 2003 May 1;187(9):1397-403
– reference: 9462923 - AIDS Res Hum Retroviruses. 1998 Jan 20;14(2):129-38
– reference: 9971817 - J Virol. 1999 Mar;73(3):2343-9
– reference: 9573273 - J Virol. 1998 Jun;72(6):5035-45
– reference: 14645592 - J Virol. 2003 Dec;77(24):13376-88
– reference: 16973562 - J Virol. 2006 Oct;80(19):9586-98
– reference: 8798972 - AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):877-83
– reference: 15994794 - J Virol. 2005 Jul;79(14):9006-18
– reference: 16339909 - Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18514-9
– reference: 9641677 - Nature. 1998 Jun 18;393(6686):648-59
– reference: 10318947 - Proc Natl Acad Sci U S A. 1999 May 11;96(10):5698-703
– reference: 17310935 - J Acquir Immune Defic Syndr. 2007 May 1;45(1):28-33
– reference: 10954535 - J Virol. 2000 Sep;74(18):8358-67
– reference: 10559284 - J Virol. 1999 Dec;73(12):9741-55
– reference: 12543651 - Antimicrob Agents Chemother. 2003 Feb;47(2):509-17
– reference: 7816094 - Nature. 1995 Jan 12;373(6510):123-6
– reference: 15365095 - J Exp Med. 2004 Sep 20;200(6):761-70
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Snippet Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
Human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein modifications over the course of infection have been associated with coreceptor switching and...
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StartPage 9694
SubjectTerms Biological and medical sciences
CD4 Antigens - metabolism
Cell Line
Fundamental and applied biological sciences. Psychology
Genotype
HIV Infections - metabolism
HIV Infections - virology
HIV-1 - metabolism
Humans
Inhibitory Concentration 50
Kinetics
Macrophages - virology
Microbiology
Miscellaneous
Models, Biological
Monocytes - virology
Polymerase Chain Reaction
Protein Structure, Tertiary
Receptors, CCR5 - metabolism
Viral Envelope Proteins - metabolism
Virology
Virus-Cell Interactions
Title Human Immunodeficiency Virus Type 1 V1-to-V5 Envelope Variants from the Chronic Phase of Infection Use CCR5 and Fuse More Efficiently than Those from Early after Infection
URI http://jvi.asm.org/content/83/19/9694.abstract
https://www.ncbi.nlm.nih.gov/pubmed/19625411
https://www.proquest.com/docview/67642623
https://pubmed.ncbi.nlm.nih.gov/PMC2748008
Volume 83
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