Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450 - Bansal, Sumit; Maharao, Neha; Paine, Mary F.; Unadkat, Jashvant D. (Drug metabolism and disposition, 2020)
Keywords: Administration, Oral; Adult; Cannabidiol - administration & dosage; Cannabidiol - pharmacokinetics; Cytochrome P-450 Enzyme Inhibitors - administration & dosage; Cytochrome P-450 Enzyme Inhibitors - pharmacokinetics; Cytochrome P-450 Enzyme System - metabolism; Dronabinol - administration & dosage; Dronabinol - pharmacokinetics; Drug Evaluation, Preclinical; Drug Interactions; Humans; Inhibitory Concentration 50; Microsomes, Liver; Special Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions; G6P; FDA; CBD; HLM; PBPK; FaSSIF; THC; 11-OH-THC; AUC; BSA; LC-MS/MS; COOH-THC; FeSSIF; UPLC; TDI; CYP; AUCR