Integrative proteomics and m6A microarray analyses of the signatures induced by METTL3 reveals prognostically significant in gastric cancer by affecting cellular metabolism

• Published in: Frontiers in oncology Vol. 12; p. 996329
• Main Authors: Peng, Guisen, Chen, Shuran, Zheng, Ni, Tang, Yuan, Su, Xu, Wang, Jing, Dong, Rui, Wu, Di, Hu, Mingjie, Zhao, Yunli, Liu, Mulin, Wu, Huazhang
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 16.11.2022
• Subjects: gastric cancer; m6A; METTL3; Oncology; oxidative phosphorylation; prognosis

METTL3-mediated RNA N6-methyladenosine (m6A) is the most prevalent modification that participates in tumor initiation and progression via governing the expression of their target genes in cancers. However, its role in tumor cell metabolism remains poorly characterized. In this study, m6A microarray...