Delta-Aminolevulinic Acid-Mediated Photodiagnoses in Surgical Oncology: A Historical Review of Clinical Trials

• Published in: Frontiers in surgery Vol. 6; p. 45
• Main Authors: Georges, Joseph F., Valeri, Amber, Wang, Huan, Brooking, Aaron, Kakareka, Michael, Cho, Steve S., Al-Atrache, Zein, Bamimore, Michael, Osman, Hany, Ifrach, Joseph, Yu, Si, Li, Carrie, Appelt, Denah, Lee, John Y. K., Nakaji, Peter, Brill, Kristin, Yocom, Steven
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 04.09.2019
• Subjects: 5ALA; fluorescence; glioma; neurosurgery; protoporphyrin IX; Surgery

Fluorescence imaging is an emerging clinical technique for real-time intraoperative visualization of tumors and their boundaries. Though multiple fluorescent contrast agents are available in the basic sciences, few fluorescence agents are available for clinical use. Of the clinical fluorophores, del...