pH-responsive micelles and vesicles formed from a water-soluble schizophrenic diblock copolymer
•A well-controlled and structured pH-responsive double hydrophilic diblock copolymer was prepared via reversible addition–fragmentation chain transfer (RAFT) controlled/living radical polymerization.•In aqueous solution the block copolymer self-assembles to a schizophrenic micelle under acidic and b...
Saved in:
| Published in | Journal of the Taiwan Institute of Chemical Engineers Vol. 45; no. 6; pp. 3117 - 3123 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.11.2014
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | •A well-controlled and structured pH-responsive double hydrophilic diblock copolymer was prepared via reversible addition–fragmentation chain transfer (RAFT) controlled/living radical polymerization.•In aqueous solution the block copolymer self-assembles to a schizophrenic micelle under acidic and basic conditions.•In pure water the block copolymer forms vesicles that can incorporate guest water-soluble polymers into the interior water phase.
A pH-responsive diblock polymer (pDEA-b-pAaH) composed of poly(N,N-diethylaminoethyl methacrylate) (pDEA) and poly(6-acrylamidohexanoic acid) (pAaH) was synthesized via reversible addition-fragmentation chain transfer (RAFT) controlled/living radical polymerization and characterized by NMR. pDEA-b-pAaH in water and salt solution self-assembled to schizophrenic micelles in acidic and basic conditions. NMR, light scattering, TEM, and fluorescence measurements provided clear evidence of core–shell micelles and inverted micelles under acidic and basic pH conditions. The micelle size was determined by dynamic light scattering (DLS) measurement at different pH values. pDEA-b-pAaH does not dissolve in water at around pH 6, because the anionic pAaH and cationic pDEA blocks were subject to electrostatic interactions; however, the precipitate formed in pure water at pH 6 dissolved in 1.1M NaCl because the electrostatic interactions were screened by the large excess of NaCl. When pDEA-b-pAaH in 1.1M NaCl aqueous solution was dialyzed against pure water to remove NaCl, the polymer formed a vesicle structure that could incorporate water-soluble polymer guest molecules into the interior water phase. |
|---|---|
| AbstractList | •A well-controlled and structured pH-responsive double hydrophilic diblock copolymer was prepared via reversible addition–fragmentation chain transfer (RAFT) controlled/living radical polymerization.•In aqueous solution the block copolymer self-assembles to a schizophrenic micelle under acidic and basic conditions.•In pure water the block copolymer forms vesicles that can incorporate guest water-soluble polymers into the interior water phase.
A pH-responsive diblock polymer (pDEA-b-pAaH) composed of poly(N,N-diethylaminoethyl methacrylate) (pDEA) and poly(6-acrylamidohexanoic acid) (pAaH) was synthesized via reversible addition-fragmentation chain transfer (RAFT) controlled/living radical polymerization and characterized by NMR. pDEA-b-pAaH in water and salt solution self-assembled to schizophrenic micelles in acidic and basic conditions. NMR, light scattering, TEM, and fluorescence measurements provided clear evidence of core–shell micelles and inverted micelles under acidic and basic pH conditions. The micelle size was determined by dynamic light scattering (DLS) measurement at different pH values. pDEA-b-pAaH does not dissolve in water at around pH 6, because the anionic pAaH and cationic pDEA blocks were subject to electrostatic interactions; however, the precipitate formed in pure water at pH 6 dissolved in 1.1M NaCl because the electrostatic interactions were screened by the large excess of NaCl. When pDEA-b-pAaH in 1.1M NaCl aqueous solution was dialyzed against pure water to remove NaCl, the polymer formed a vesicle structure that could incorporate water-soluble polymer guest molecules into the interior water phase. |
| Author | Bahadur, Pratap Khimani, Mehul Enomoto, Ryusuke Yusa, Shin-ichi |
| Author_xml | – sequence: 1 givenname: Ryusuke surname: Enomoto fullname: Enomoto, Ryusuke organization: Department of Materials Science and Chemistry, University of Hyogo, 2167 Shosha, Himeji 671-2280, Japan – sequence: 2 givenname: Mehul surname: Khimani fullname: Khimani, Mehul organization: Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, India – sequence: 3 givenname: Pratap surname: Bahadur fullname: Bahadur, Pratap organization: Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, India – sequence: 4 givenname: Shin-ichi surname: Yusa fullname: Yusa, Shin-ichi email: yusa@eng.u-hyogo.ac.jp organization: Department of Materials Science and Chemistry, University of Hyogo, 2167 Shosha, Himeji 671-2280, Japan |
| BookMark | eNqFkMFKxDAQhoOs4Kr7BF7yAq1J06btwYMs6goLXvQc0umUTU2bktSV9eltXfHgQYcfZobh-2H-c7LoXY-EXHEWc8bldRu3owGME8bTmE3i4oQseZHLiLOiXPzMOTsjqxBaNlfOkiRbEjVsIo9hcH0we6TdZGQtBqr7mu4xGJiXxvkOa9p411FN3_WIPgrOvlUWaYCd-XDDzmNvgNamsg5eKbjB2UOH_pKcNtoGXH33C_Jyf_e83kTbp4fH9e02glSUYyRECjpFpota5hKkbDQTZZKxKqvnmi4yZyUXVYqFQKgKmWEBBSSClwK5uCDi6AveheCxUYM3nfYHxZmaY1Kt-opJzTEpNomLiSp_UWBGPRrXj14b-w97c2Rxemtv0KsABnvA2niEUdXO_Ml_AnVgiMU |
| CitedBy_id | crossref_primary_10_1039_D0BM01283A crossref_primary_10_1021_acs_langmuir_8b01684 crossref_primary_10_1007_s42114_018_0059_9 crossref_primary_10_1016_j_reactfunctpolym_2020_104544 crossref_primary_10_1039_D0TB00475H crossref_primary_10_1007_s00289_019_03046_w crossref_primary_10_1016_j_molliq_2021_116754 crossref_primary_10_1246_cl_210135 crossref_primary_10_1002_masy_201500145 |
| Cites_doi | 10.1021/jp9038896 10.1021/ma9615617 10.1002/masy.19950980156 10.1002/marc.200400510 10.1021/ma030065x 10.1039/b505212b 10.1016/j.progpolymsci.2007.05.009 10.1021/la020951l 10.1021/ma0114842 10.1016/S0079-6700(03)00015-7 10.1021/la046830y 10.1002/1521-3773(20020415)41:8<1413::AID-ANIE1413>3.0.CO;2-K 10.1021/ma070769x 10.1021/ma00090a007 10.1021/ja012167d 10.1016/j.progpolymsci.2009.11.005 10.1021/ja043920g 10.1021/je000381w 10.1039/b807696k 10.1002/pi.2277 10.1021/ma0018087 10.1039/b714741d 10.1002/1521-4095(20020219)14:4<300::AID-ADMA300>3.0.CO;2-P 10.1016/j.cis.2006.05.016 10.1016/j.reactfunctpolym.2005.07.021 10.1021/la300332x 10.1021/ma0600254 10.1021/ma035838w 10.1016/j.addr.2006.09.020 10.1016/S0032-3861(01)00066-0 10.1016/j.progpolymsci.2007.07.001 10.1021/la2038119 10.1295/polymj.37.480 10.1021/ma035059f |
| ContentType | Journal Article |
| Copyright | 2014 Taiwan Institute of Chemical Engineers |
| Copyright_xml | – notice: 2014 Taiwan Institute of Chemical Engineers |
| DBID | AAYXX CITATION |
| DOI | 10.1016/j.jtice.2014.04.013 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Economics Engineering |
| EISSN | 1876-1089 |
| EndPage | 3123 |
| ExternalDocumentID | 10_1016_j_jtice_2014_04_013 S1876107014001187 |
| GroupedDBID | --K --M .DC .~1 0R~ 1B1 1~. 1~5 4.4 457 4G. 5VS 7-5 71M 8P~ 8RM AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAXUO ABFNM ABJNI ABMAC ABNUV ABXDB ABYKQ ACDAQ ACGFS ACRLP ADBBV ADEWK ADEZE ADMUD AEBSH AEKER AENEX AFKWA AFTJW AGHFR AGUBO AGYEJ AHPOS AIEXJ AIKHN AITUG AJBFU AJOXV AKURH ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC DU5 EBS EFJIC EFLBG EJD ENUVR EP2 EP3 FDB FEDTE FIRID FNPLU FYGXN GBLVA HVGLF HZ~ J1W KOM M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 RIG ROL SDF SES SPC SPCBC SSG SSZ T5K ~G- AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AFXIZ AGCQF AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH |
| ID | FETCH-LOGICAL-c439t-334ca4e0a8d676c66fa039250b5ddddde0a670913b4e83ecb865e8c8c23193e13 |
| IEDL.DBID | .~1 |
| ISSN | 1876-1070 |
| IngestDate | Tue Jul 01 00:40:38 EDT 2025 Thu Apr 24 23:09:43 EDT 2025 Fri Feb 23 02:26:12 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | Vesicle Micelle Water-soluble polymer Controlled/living radical polymerization Block copolymer |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c439t-334ca4e0a8d676c66fa039250b5ddddde0a670913b4e83ecb865e8c8c23193e13 |
| PageCount | 7 |
| ParticipantIDs | crossref_primary_10_1016_j_jtice_2014_04_013 crossref_citationtrail_10_1016_j_jtice_2014_04_013 elsevier_sciencedirect_doi_10_1016_j_jtice_2014_04_013 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2014-11-01 |
| PublicationDateYYYYMMDD | 2014-11-01 |
| PublicationDate_xml | – month: 11 year: 2014 text: 2014-11-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationTitle | Journal of the Taiwan Institute of Chemical Engineers |
| PublicationYear | 2014 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Kathmann, Davis, McCormick (bib0150) 1994; 27 Rodriguez-Hernandez, Lecommandoux (bib0050) 2005; 127 Hamley (bib0020) 2005 Xu, Liu, Polymeric nanocarriers possessing thermoresponsive coronas (bib0075) 2008; 4 Riess, Hurtrez, Bahadur (bib0005) 1985; vol. 2 Robin, Dreiss, Cosgrove, Armes, Thompson, Baines, Billingham (bib0090) 2005; 21 Crespy, Rossi (bib0100) 2007; 56 Weaver, Armes, Liu (bib0125) 2003; 36 Rodríguez-Hernández, Lecommandoux (bib0165) 2005; 127 Mitsukami, Donovan, Lowe, McCormick (bib0170) 2001; 34 Tuzar, Pospisil, Plestil, Lowe, Baines, Billingham, Armes (bib0155) 1997; 30 Zhao, Zhang, Pispas (bib0120) 2009; 113 Wang, Li, Li, Wang, Li, Dai (bib0185) 2001; 46 Smith, Xu, McCormick (bib0030) 2010; 35 Bütün, Liu, Weaver, Bories-Azeau, Cai, Armes (bib0025) 2006; 66 Khutoryanskiy, Dubolazov, Mun (bib0065) 2008 Hoffman (bib0105) 1995; 98 Yusa, Shimada, Mitsukami, Yamamoto, Morishima (bib0045) 2003; 36 Rapoport (bib0115) 2007; 32 Riess (bib0010) 2003; 28 Arotçaréna, Heise, Ishaya, Laschewsky (bib0080) 2002; 124 Yusa, Konishi, Mitsukami, Yamamoto, Morishima (bib0195) 2005; 37 André, Zhang, Müller (bib0130) 2005; 26 Yerushalmi, Scherz, van der Boom, Kraatz (bib0095) 2005; 15 Nakashima, Bahadur (bib0015) 2006; 123–126 Dimitrov, Trzebicka, Müller, Dworak, Tsvetanov (bib0040) 2007; 32 Dai, Ravi, Tam (bib0055) 2008; 4 Liu, Armes (bib0160) 2003; 19 Qi, Li, Ma (bib0085) 2002; 14 Liu, Armes (bib0145) 2002; 41 Xiaohui, Changjun, Jinghong, Jian (bib0140) 2011; 23 Bütün, Armes, Billingham (bib0180) 2001; 42 Adamczyk, Bratek-Skicki, Dabrowska, Nattich-Rak (bib0175) 2012; 28 McCormick (bib0035) 2001; 780 Schmaljohann (bib0110) 2006; 58 Deng, Goldys (bib0200) 2012; 28 Lee, Bütün, Vamvakaki, Armes, Pople, Gast (bib0060) 2002; 35 Kujawa, Tanaka, Winnik (bib0190) 2006; 39 Schilli, Zhang, Rizzardo, Thang, Chong, Edwards, Karlsson, Müller (bib0070) 2004; 37 Yusa, Yamago, Sugahara, Morikawa, Yamamoto, Morishima (bib0135) 2007; 40 Hamley (10.1016/j.jtice.2014.04.013_bib0020) 2005 Riess (10.1016/j.jtice.2014.04.013_bib0010) 2003; 28 McCormick (10.1016/j.jtice.2014.04.013_bib0035) 2001; 780 Lee (10.1016/j.jtice.2014.04.013_bib0060) 2002; 35 Rodriguez-Hernandez (10.1016/j.jtice.2014.04.013_bib0050) 2005; 127 Rapoport (10.1016/j.jtice.2014.04.013_bib0115) 2007; 32 André (10.1016/j.jtice.2014.04.013_bib0130) 2005; 26 Nakashima (10.1016/j.jtice.2014.04.013_bib0015) 2006; 123–126 Yerushalmi (10.1016/j.jtice.2014.04.013_bib0095) 2005; 15 Khutoryanskiy (10.1016/j.jtice.2014.04.013_bib0065) 2008 Bütün (10.1016/j.jtice.2014.04.013_bib0180) 2001; 42 Smith (10.1016/j.jtice.2014.04.013_bib0030) 2010; 35 Crespy (10.1016/j.jtice.2014.04.013_bib0100) 2007; 56 Schmaljohann (10.1016/j.jtice.2014.04.013_bib0110) 2006; 58 Arotçaréna (10.1016/j.jtice.2014.04.013_bib0080) 2002; 124 Hoffman (10.1016/j.jtice.2014.04.013_bib0105) 1995; 98 Tuzar (10.1016/j.jtice.2014.04.013_bib0155) 1997; 30 Deng (10.1016/j.jtice.2014.04.013_bib0200) 2012; 28 Schilli (10.1016/j.jtice.2014.04.013_bib0070) 2004; 37 Liu (10.1016/j.jtice.2014.04.013_bib0160) 2003; 19 Kujawa (10.1016/j.jtice.2014.04.013_bib0190) 2006; 39 Dimitrov (10.1016/j.jtice.2014.04.013_bib0040) 2007; 32 Zhao (10.1016/j.jtice.2014.04.013_bib0120) 2009; 113 Wang (10.1016/j.jtice.2014.04.013_bib0185) 2001; 46 Yusa (10.1016/j.jtice.2014.04.013_bib0135) 2007; 40 Riess (10.1016/j.jtice.2014.04.013_bib0005) 1985; vol. 2 Kathmann (10.1016/j.jtice.2014.04.013_bib0150) 1994; 27 Qi (10.1016/j.jtice.2014.04.013_bib0085) 2002; 14 Adamczyk (10.1016/j.jtice.2014.04.013_bib0175) 2012; 28 Xiaohui (10.1016/j.jtice.2014.04.013_bib0140) 2011; 23 Yusa (10.1016/j.jtice.2014.04.013_bib0195) 2005; 37 Dai (10.1016/j.jtice.2014.04.013_bib0055) 2008; 4 Bütün (10.1016/j.jtice.2014.04.013_bib0025) 2006; 66 Weaver (10.1016/j.jtice.2014.04.013_bib0125) 2003; 36 Liu (10.1016/j.jtice.2014.04.013_bib0145) 2002; 41 Robin (10.1016/j.jtice.2014.04.013_bib0090) 2005; 21 Mitsukami (10.1016/j.jtice.2014.04.013_bib0170) 2001; 34 Yusa (10.1016/j.jtice.2014.04.013_bib0045) 2003; 36 Rodríguez-Hernández (10.1016/j.jtice.2014.04.013_bib0165) 2005; 127 Xu (10.1016/j.jtice.2014.04.013_bib0075) 2008; 4 |
| References_xml | – volume: 123–126 start-page: 75 year: 2006 end-page: 96 ident: bib0015 article-title: Aggregation of water-soluble block copolymers in aqueous solutions: recent trends publication-title: Adv Colloid Interface Sci – volume: 34 start-page: 2248 year: 2001 end-page: 2256 ident: bib0170 article-title: Water-soluble polymers. 81. Direct synthesis of hydrophilic styrenic-based homopolymers and block copolymers in aqueous solution via RAFT publication-title: Macromolecules – volume: 46 start-page: 831 year: 2001 end-page: 837 ident: bib0185 article-title: Extraction equilibria of monocarboxylic acids with trialkylphosphine oxide publication-title: J Chem Eng Data – volume: 98 start-page: 645 year: 1995 end-page: 664 ident: bib0105 article-title: “Intelligent” polymers in medicine and biotechnology publication-title: Macromol Symp – year: 2005 ident: bib0020 article-title: Block copolymers in solution: fundamentals and applications – volume: 14 start-page: 300 year: 2002 ident: bib0085 article-title: Biomimetic morphogenesis of calcium carbonate in mixed solutions of surfactants and double-hydrophilic block copolymers publication-title: Adv Mater – volume: 21 start-page: 4856 year: 2005 end-page: 4861 ident: bib0090 article-title: Structure of a hydrophilic–hydrophobic block copolymer and its interactions with salt and an anionic surfactant publication-title: Langmuir – volume: 26 start-page: 558 year: 2005 end-page: 563 ident: bib0130 article-title: Thermo-and pH-responsive micelles of poly(acrylic acid)- publication-title: Macromol Rapid Commun – volume: 58 start-page: 1655 year: 2006 end-page: 1670 ident: bib0110 article-title: Thermo- and pH-responsive polymers in drug delivery publication-title: Adv Drug Delivery Rev – volume: 127 start-page: 2026 year: 2005 end-page: 2027 ident: bib0165 article-title: Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers publication-title: J Am Chem Soc – volume: 37 start-page: 480 year: 2005 end-page: 488 ident: bib0195 article-title: pH-responsive micellization of amine-containing cationic diblock copolymers prepared by reversible addition-fragmentation chain transfer (RAFT) radical polymerization publication-title: Polym J – volume: 36 start-page: 9994 year: 2003 end-page: 9998 ident: bib0125 article-title: A “Holy trinity” of micellar aggregates in aqueous solution at ambient temperature: unprecedented self-assembly behavior from a binary mixture of a neutral-cationic diblock copolymer and an anionic polyelectrolyte publication-title: Macromolecules – start-page: 1 year: 2008 end-page: 21 ident: bib0065 article-title: pH-and ionic strength effects on interpolymer complexation via hydrogen-bonding publication-title: Hydrogen-bonded interpolymer complexes: formation, structure and applications – volume: 66 start-page: 157 year: 2006 end-page: 165 ident: bib0025 article-title: A brief review of ‘schizophrenic’ block copolymers publication-title: React Funct Polym – volume: 35 start-page: 8540 year: 2002 end-page: 8551 ident: bib0060 article-title: Structure of pH-dependent block copolymer micelles: charge and ionic strength dependence publication-title: Macromolecules – volume: 124 start-page: 3787 year: 2002 end-page: 3793 ident: bib0080 article-title: Switching the inside and the outside of aggregates of water-soluble block copolymers with double thermoresponsivity publication-title: J Am Chem Soc – volume: vol. 2 year: 1985 ident: bib0005 article-title: Block copolymers publication-title: Encyclopedia of polymer science and engineering – volume: 19 start-page: 4432 year: 2003 end-page: 4438 ident: bib0160 article-title: Synthesis and aqueous solution behavior of a pH-responsive schizophrenic diblock copolymer publication-title: Langmuir – volume: 56 start-page: 1461 year: 2007 end-page: 1468 ident: bib0100 article-title: Temperature-responsive polymers with LCST in the physiological range and their applications in textiles publication-title: Polym Int – volume: 23 start-page: 781 year: 2011 end-page: 790 ident: bib0140 article-title: Schizophrenic micellization of block copolymers publication-title: Prog Chem – volume: 30 start-page: 2509 year: 1997 end-page: 2512 ident: bib0155 article-title: Micelles of hydrophilic–hydrophobic poly(sulfobetaine)-based block copolymers publication-title: Macromolecules – volume: 40 start-page: 5907 year: 2007 end-page: 5915 ident: bib0135 article-title: Thermo-responsive diblock copolymers of poly( publication-title: Macromolecules – volume: 28 start-page: 10152 year: 2012 end-page: 10163 ident: bib0200 article-title: Plasmonic approach to enhanced fluorescence for applications in biotechnology and the life sciences publication-title: Langmuir – volume: 32 start-page: 1275 year: 2007 end-page: 1343 ident: bib0040 article-title: Thermosensitive water-soluble copolymers with doubly responsive reversibly interacting entities publication-title: Prog Polym Sci – volume: 41 start-page: 1413 year: 2002 end-page: 1416 ident: bib0145 article-title: Polymeric surfactants for the new millennium: a pH-responsive, zwitterionic, schizophrenic diblock copolymer publication-title: Angew Chem Int Ed – volume: 113 start-page: 10600 year: 2009 end-page: 10606 ident: bib0120 article-title: Thermo-induced aggregation behavior of poly(ethylene oxide)- publication-title: J Phys Chem B – volume: 127 start-page: 2026 year: 2005 end-page: 2027 ident: bib0050 article-title: Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers publication-title: J Am Chem Soc – volume: 42 start-page: 5993 year: 2001 end-page: 6008 ident: bib0180 article-title: Synthesis and aqueous solution properties of near-monodisperse tertiary amine methacrylate homopolymers and diblock copolymers publication-title: Polymer – volume: 39 start-page: 3048 year: 2006 end-page: 3055 ident: bib0190 article-title: Temperature-dependent properties of telechelic hydrophobically modified poly( publication-title: Macromolecules – volume: 28 start-page: 1107 year: 2003 end-page: 1170 ident: bib0010 article-title: Micellization of block copolymers publication-title: Prog Polym Sci – volume: 15 start-page: 4480 year: 2005 end-page: 4487 ident: bib0095 article-title: Stimuli responsive materials: new avenues toward smart organic devices publication-title: J Mater Chem – volume: 28 start-page: 474 year: 2012 end-page: 485 ident: bib0175 article-title: Mechanisms of fibrinogen adsorption on latex particles determined by zeta potential and AFM measurements publication-title: Langmuir – volume: 780 start-page: 1 year: 2001 end-page: 132 ident: bib0035 article-title: Stimuli-responsive water soluble and amphiphilic (co) polymers publication-title: ACS Symp Ser – volume: 36 start-page: 4208 year: 2003 end-page: 4215 ident: bib0045 article-title: pH-responsive micellization of amphiphilic diblock copolymers synthesized via reversible addition-fragmentation chain transfer polymerization publication-title: Macromolecules – volume: 37 start-page: 7861 year: 2004 end-page: 7866 ident: bib0070 article-title: A new double-responsive block copolymer synthesized via RAFT polymerization: poly( publication-title: Macromolecules – volume: 27 start-page: 3156 year: 1994 end-page: 3161 ident: bib0150 article-title: Water-soluble polymers, 60. Synthesis and solution behavior of terpolymers of acrylic acid, acrylamide, and the zwitterionic monomer 3-[(2-acrylamido-2-methylpropyl) dimethylammonio]-1-propanesulfonate publication-title: Macromolecules – volume: 32 start-page: 962 year: 2007 end-page: 990 ident: bib0115 article-title: Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery publication-title: Prog Polym Sci – volume: 35 start-page: 45 year: 2010 end-page: 93 ident: bib0030 article-title: Stimuli-responsive amphiphilic (co) polymers via RAFT polymerization publication-title: Prog Polym Sci – volume: 4 start-page: 1745 year: 2008 end-page: 1749 ident: bib0075 publication-title: Soft Matter – volume: 4 start-page: 435 year: 2008 end-page: 449 ident: bib0055 article-title: pH-Responsive polymers: synthesis, properties and applications publication-title: Soft Matter – volume: 113 start-page: 10600 year: 2009 ident: 10.1016/j.jtice.2014.04.013_bib0120 article-title: Thermo-induced aggregation behavior of poly(ethylene oxide)-b-poly(N-isopropylacrylamide) block copolymers in the presence of cationic surfactants publication-title: J Phys Chem B doi: 10.1021/jp9038896 – volume: 30 start-page: 2509 year: 1997 ident: 10.1016/j.jtice.2014.04.013_bib0155 article-title: Micelles of hydrophilic–hydrophobic poly(sulfobetaine)-based block copolymers publication-title: Macromolecules doi: 10.1021/ma9615617 – volume: 98 start-page: 645 year: 1995 ident: 10.1016/j.jtice.2014.04.013_bib0105 article-title: “Intelligent” polymers in medicine and biotechnology publication-title: Macromol Symp doi: 10.1002/masy.19950980156 – volume: 26 start-page: 558 year: 2005 ident: 10.1016/j.jtice.2014.04.013_bib0130 article-title: Thermo-and pH-responsive micelles of poly(acrylic acid)-block-poly (N,N-diethylacrylamide) publication-title: Macromol Rapid Commun doi: 10.1002/marc.200400510 – volume: 36 start-page: 4208 year: 2003 ident: 10.1016/j.jtice.2014.04.013_bib0045 article-title: pH-responsive micellization of amphiphilic diblock copolymers synthesized via reversible addition-fragmentation chain transfer polymerization publication-title: Macromolecules doi: 10.1021/ma030065x – volume: 15 start-page: 4480 year: 2005 ident: 10.1016/j.jtice.2014.04.013_bib0095 article-title: Stimuli responsive materials: new avenues toward smart organic devices publication-title: J Mater Chem doi: 10.1039/b505212b – volume: 23 start-page: 781 year: 2011 ident: 10.1016/j.jtice.2014.04.013_bib0140 article-title: Schizophrenic micellization of block copolymers publication-title: Prog Chem – volume: 780 start-page: 1 year: 2001 ident: 10.1016/j.jtice.2014.04.013_bib0035 article-title: Stimuli-responsive water soluble and amphiphilic (co) polymers publication-title: ACS Symp Ser – volume: 32 start-page: 962 year: 2007 ident: 10.1016/j.jtice.2014.04.013_bib0115 article-title: Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery publication-title: Prog Polym Sci doi: 10.1016/j.progpolymsci.2007.05.009 – volume: 19 start-page: 4432 year: 2003 ident: 10.1016/j.jtice.2014.04.013_bib0160 article-title: Synthesis and aqueous solution behavior of a pH-responsive schizophrenic diblock copolymer publication-title: Langmuir doi: 10.1021/la020951l – volume: 35 start-page: 8540 year: 2002 ident: 10.1016/j.jtice.2014.04.013_bib0060 article-title: Structure of pH-dependent block copolymer micelles: charge and ionic strength dependence publication-title: Macromolecules doi: 10.1021/ma0114842 – volume: 28 start-page: 1107 year: 2003 ident: 10.1016/j.jtice.2014.04.013_bib0010 article-title: Micellization of block copolymers publication-title: Prog Polym Sci doi: 10.1016/S0079-6700(03)00015-7 – volume: 21 start-page: 4856 year: 2005 ident: 10.1016/j.jtice.2014.04.013_bib0090 article-title: Structure of a hydrophilic–hydrophobic block copolymer and its interactions with salt and an anionic surfactant publication-title: Langmuir doi: 10.1021/la046830y – volume: 41 start-page: 1413 year: 2002 ident: 10.1016/j.jtice.2014.04.013_bib0145 article-title: Polymeric surfactants for the new millennium: a pH-responsive, zwitterionic, schizophrenic diblock copolymer publication-title: Angew Chem Int Ed doi: 10.1002/1521-3773(20020415)41:8<1413::AID-ANIE1413>3.0.CO;2-K – volume: 40 start-page: 5907 year: 2007 ident: 10.1016/j.jtice.2014.04.013_bib0135 article-title: Thermo-responsive diblock copolymers of poly(N-isopropylacrylamide) and poly(N-vinyl-2-pyrroridone) synthesized via organotellurium-mediated controlled radical polymerization (TERP) publication-title: Macromolecules doi: 10.1021/ma070769x – volume: 27 start-page: 3156 year: 1994 ident: 10.1016/j.jtice.2014.04.013_bib0150 article-title: Water-soluble polymers, 60. Synthesis and solution behavior of terpolymers of acrylic acid, acrylamide, and the zwitterionic monomer 3-[(2-acrylamido-2-methylpropyl) dimethylammonio]-1-propanesulfonate publication-title: Macromolecules doi: 10.1021/ma00090a007 – volume: 124 start-page: 3787 year: 2002 ident: 10.1016/j.jtice.2014.04.013_bib0080 article-title: Switching the inside and the outside of aggregates of water-soluble block copolymers with double thermoresponsivity publication-title: J Am Chem Soc doi: 10.1021/ja012167d – volume: 35 start-page: 45 year: 2010 ident: 10.1016/j.jtice.2014.04.013_bib0030 article-title: Stimuli-responsive amphiphilic (co) polymers via RAFT polymerization publication-title: Prog Polym Sci doi: 10.1016/j.progpolymsci.2009.11.005 – volume: 127 start-page: 2026 year: 2005 ident: 10.1016/j.jtice.2014.04.013_bib0165 article-title: Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers publication-title: J Am Chem Soc doi: 10.1021/ja043920g – volume: 46 start-page: 831 year: 2001 ident: 10.1016/j.jtice.2014.04.013_bib0185 article-title: Extraction equilibria of monocarboxylic acids with trialkylphosphine oxide publication-title: J Chem Eng Data doi: 10.1021/je000381w – volume: 4 start-page: 1745 year: 2008 ident: 10.1016/j.jtice.2014.04.013_bib0075 publication-title: Soft Matter doi: 10.1039/b807696k – volume: 56 start-page: 1461 year: 2007 ident: 10.1016/j.jtice.2014.04.013_bib0100 article-title: Temperature-responsive polymers with LCST in the physiological range and their applications in textiles publication-title: Polym Int doi: 10.1002/pi.2277 – volume: 34 start-page: 2248 year: 2001 ident: 10.1016/j.jtice.2014.04.013_bib0170 article-title: Water-soluble polymers. 81. Direct synthesis of hydrophilic styrenic-based homopolymers and block copolymers in aqueous solution via RAFT publication-title: Macromolecules doi: 10.1021/ma0018087 – volume: vol. 2 year: 1985 ident: 10.1016/j.jtice.2014.04.013_bib0005 article-title: Block copolymers – volume: 4 start-page: 435 year: 2008 ident: 10.1016/j.jtice.2014.04.013_bib0055 article-title: pH-Responsive polymers: synthesis, properties and applications publication-title: Soft Matter doi: 10.1039/b714741d – volume: 14 start-page: 300 year: 2002 ident: 10.1016/j.jtice.2014.04.013_bib0085 article-title: Biomimetic morphogenesis of calcium carbonate in mixed solutions of surfactants and double-hydrophilic block copolymers publication-title: Adv Mater doi: 10.1002/1521-4095(20020219)14:4<300::AID-ADMA300>3.0.CO;2-P – volume: 123–126 start-page: 75 year: 2006 ident: 10.1016/j.jtice.2014.04.013_bib0015 article-title: Aggregation of water-soluble block copolymers in aqueous solutions: recent trends publication-title: Adv Colloid Interface Sci doi: 10.1016/j.cis.2006.05.016 – volume: 66 start-page: 157 year: 2006 ident: 10.1016/j.jtice.2014.04.013_bib0025 article-title: A brief review of ‘schizophrenic’ block copolymers publication-title: React Funct Polym doi: 10.1016/j.reactfunctpolym.2005.07.021 – volume: 28 start-page: 10152 year: 2012 ident: 10.1016/j.jtice.2014.04.013_bib0200 article-title: Plasmonic approach to enhanced fluorescence for applications in biotechnology and the life sciences publication-title: Langmuir doi: 10.1021/la300332x – start-page: 1 year: 2008 ident: 10.1016/j.jtice.2014.04.013_bib0065 article-title: pH-and ionic strength effects on interpolymer complexation via hydrogen-bonding – year: 2005 ident: 10.1016/j.jtice.2014.04.013_bib0020 – volume: 39 start-page: 3048 year: 2006 ident: 10.1016/j.jtice.2014.04.013_bib0190 article-title: Temperature-dependent properties of telechelic hydrophobically modified poly(N-isopropylacrylamides) in water: evidence from light scattering and fluorescence spectroscopy for the formation of stable mesoglobules at elevated temperatures publication-title: Macromolecules doi: 10.1021/ma0600254 – volume: 37 start-page: 7861 year: 2004 ident: 10.1016/j.jtice.2014.04.013_bib0070 article-title: A new double-responsive block copolymer synthesized via RAFT polymerization: poly(N-isopropylacrylamide)-block-poly(acrylic acid) publication-title: Macromolecules doi: 10.1021/ma035838w – volume: 58 start-page: 1655 year: 2006 ident: 10.1016/j.jtice.2014.04.013_bib0110 article-title: Thermo- and pH-responsive polymers in drug delivery publication-title: Adv Drug Delivery Rev doi: 10.1016/j.addr.2006.09.020 – volume: 42 start-page: 5993 year: 2001 ident: 10.1016/j.jtice.2014.04.013_bib0180 article-title: Synthesis and aqueous solution properties of near-monodisperse tertiary amine methacrylate homopolymers and diblock copolymers publication-title: Polymer doi: 10.1016/S0032-3861(01)00066-0 – volume: 32 start-page: 1275 year: 2007 ident: 10.1016/j.jtice.2014.04.013_bib0040 article-title: Thermosensitive water-soluble copolymers with doubly responsive reversibly interacting entities publication-title: Prog Polym Sci doi: 10.1016/j.progpolymsci.2007.07.001 – volume: 28 start-page: 474 year: 2012 ident: 10.1016/j.jtice.2014.04.013_bib0175 article-title: Mechanisms of fibrinogen adsorption on latex particles determined by zeta potential and AFM measurements publication-title: Langmuir doi: 10.1021/la2038119 – volume: 127 start-page: 2026 year: 2005 ident: 10.1016/j.jtice.2014.04.013_bib0050 article-title: Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers publication-title: J Am Chem Soc doi: 10.1021/ja043920g – volume: 37 start-page: 480 year: 2005 ident: 10.1016/j.jtice.2014.04.013_bib0195 article-title: pH-responsive micellization of amine-containing cationic diblock copolymers prepared by reversible addition-fragmentation chain transfer (RAFT) radical polymerization publication-title: Polym J doi: 10.1295/polymj.37.480 – volume: 36 start-page: 9994 year: 2003 ident: 10.1016/j.jtice.2014.04.013_bib0125 article-title: A “Holy trinity” of micellar aggregates in aqueous solution at ambient temperature: unprecedented self-assembly behavior from a binary mixture of a neutral-cationic diblock copolymer and an anionic polyelectrolyte publication-title: Macromolecules doi: 10.1021/ma035059f |
| SSID | ssj0000070225 |
| Score | 2.065787 |
| Snippet | •A well-controlled and structured pH-responsive double hydrophilic diblock copolymer was prepared via reversible addition–fragmentation chain transfer (RAFT)... |
| SourceID | crossref elsevier |
| SourceType | Enrichment Source Index Database Publisher |
| StartPage | 3117 |
| SubjectTerms | Block copolymer Controlled/living radical polymerization Micelle Vesicle Water-soluble polymer |
| Title | pH-responsive micelles and vesicles formed from a water-soluble schizophrenic diblock copolymer |
| URI | https://dx.doi.org/10.1016/j.jtice.2014.04.013 |
| Volume | 45 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NS8NAEF1KPagH0apYP8oePLo2291s02MplqjYixZ6C9nNBFprLEmtePG3u5OPUkF6MOSSZAfCZDL7dnnzhpBrozzuRp5hkQw1k9CVLLQogxkthIKeC6CxGvlppPyxfJi4kxoZVLUwSKssc3-R0_NsXd5pl95sL6bT9jO3P7JdvOASIW-ajRXssotRfvvN1_ssqGfTyXuv4niGBpX4UE7zmiHHDCleMpc85eLvCWpj0hkekoMSLdJ-8UJHpAZJg-xWxcRZg-xv6Akek2Dhs7Qkva6AYqf5-RwyGiYRXUGWM-AoolSIKNaV0JB-WqyZMgxAPQeabVDwDI2m2k51r9RgI4WvN0hPyHh49zLwWdlBgRkLNJZMCGlCCU7oRaqrjFJx6FhA5DrajfCwT1C_jQstwRNgtKdc8IxnLOrrCeDilNST9wTOCDWGa2l4bAGBTa5a9DyIVQydKDQxqv41SadyW2BKeXHscjEPKh7ZLMh9HaCvA8eeXDTJzdpoUahrbB-uqu8R_AqSwOb_bYbn_zW8IHt4VRQfXpL6Mv2AK4tClrqVh1mL7PTvH_3RD-s13fk |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NTwIxEJ34cUAPRlEjfvbg0Qql3bIcjZGgAhch4dZsu7MJikgAMV787XaWXYOJ4eBmT9udZDPbzrw2b94AXDodiiAOHY9VZLnCmuKRRxncWSk11gNES9XI7Y5u9tRDP-ivwW1eC0O0yiz2L2J6Gq2zJ-XMm-XxYFB-En4h-80LbRHSptnrsKn88qU2Btdf4ueghQRtqmnzVTLgZJGrD6U8r2cimRHHS6Wap0L-naGWsk5jF3YyuMhuFl-0B2s4KkIhryaeFmF7SVBwH8y4yScZ63WOjFrND4c4ZdEoZnOcphQ4RjAVY0aFJSxiHx5sTjjNQDtENl3i4DkWD6zPdS_MUSeFz1ecHECvcde9bfKshQJ3HmnMuJTKRQorURjrmnZaJ1HFI6KgYoOYLj9CAm5CWoWhRGdDHWDoQudhX12ikIewMXob4REw54RVTiQeEfjoamU9xEQnWI0jl5DsXwmquduMy_TFqc3F0OREsmeT-tqQr03F30KW4OrHaLyQ11j9us7_h_k1S4xPAKsMj_9reAGFZrfdMq37zuMJbNHIohLxFDZmk3c885BkZs_TKfcNGW3fhw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=pH-responsive+micelles+and+vesicles+formed+from+a+water-soluble+schizophrenic+diblock+copolymer&rft.jtitle=Journal+of+the+Taiwan+Institute+of+Chemical+Engineers&rft.au=Enomoto%2C+Ryusuke&rft.au=Khimani%2C+Mehul&rft.au=Bahadur%2C+Pratap&rft.au=Yusa%2C+Shin-ichi&rft.date=2014-11-01&rft.pub=Elsevier+B.V&rft.issn=1876-1070&rft.eissn=1876-1089&rft_id=info:doi/10.1016%2Fj.jtice.2014.04.013&rft.externalDocID=S1876107014001187 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1876-1070&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1876-1070&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1876-1070&client=summon |