Novel Aspects of the SubA Subunit of the Subtilase Cytotoxin

• Published in: Toxins Vol. 14; no. 2; p. 156
• Main Authors: Sessler, Katharina, Schmidt, Herbert, Barth, Holger
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.02.2022; MDPI
• Subjects: AB5 toxin; Apoptosis; Binding; Cell death; Cell lines; Chemical bonds; Cytotoxicity; Cytotoxins - chemistry; Cytotoxins - toxicity; E coli; Enzymatic activity; Enzymes; Escherichia coli; Experiments; Food contamination & poisoning; Genes; Kinases; Molecular Structure; Proteins; Retrograde transport; Review; Shiga toxin; Strains (organisms); SubA; SubB; Subtilase; subtilase cytotoxin; Subtilisins - chemistry; Toxins; Shiga toxin; subtilase cytotoxin; BiP/GRP78; SubB; Escherichia coli; SubA; STEC; retrograde transport; AB5 toxin; ER; cellular uptake

The subtilase cytotoxin (SubAB) belongs to the family of AB toxins and is produced together with Shiga toxin (Stx) by certain Stx-producing strains (STEC). For most AB-type toxins, it is assumed that cytotoxic effects can only be induced by a complete holotoxin complex consisting of SubA and SubB. H...