Lymphocyte Doubling Time As A Key Prognostic Factor To Predict Time To First Treatment In Early-Stage Chronic Lymphocytic Leukemia

• Published in: Frontiers in oncology Vol. 11; p. 684621
• Main Authors: Morabito, Fortunato, Tripepi, Giovanni, Moia, Riccardo, Recchia, Anna Grazia, Boggione, Paola, Mauro, Francesca Romana, Bossio, Sabrina, D’Arrigo, Graziella, Martino, Enrica Antonia, Vigna, Ernesto, Storino, Francesca, Fronza, Gilberto, Di Raimondo, Francesco, Rossi, Davide, Condoluci, Adalgisa, Colombo, Monica, Fais, Franco, Fabris, Sonia, Foa, Robin, Cutrona, Giovanna, Gentile, Massimo, Montserrat, Emili, Gaidano, Gianluca, Ferrarini, Manlio, Neri, Antonino
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 02.08.2021
• Subjects: CLL; early stage; lymphocyte doubling time; Oncology; prognosis; TTFT

The prognostic role of lymphocyte doubling time (LDT) in chronic lymphocytic leukemia (CLL) was recognized more than three decades ago when the neoplastic clone’s biology was almost unknown. LDT was defined as the time needed for the peripheral blood lymphocyte count to double the of the initial obs...