Separation and study of the range of plasminogen isoforms in patients with prostate cancer

Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plasminogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in various stages of development were included in the studied sample. With the develop...

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Published inBiochemistry (Moscow) Vol. 77; no. 9; pp. 1065 - 1071
Main Authors Shin, E. F., Vodolazhsky, D. I., Golikov, A. Yu, Belova, T. N., Boyko, N. V., Zimakov, D. V., Cherkasova, E. N., Kogan, M. I., Chibichian, M. B., Moshkovskii, S. A., Tarasov, V. A., Matishov, D. G.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 01.09.2012
Springer
Springer Nature B.V
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Abstract Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plasminogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in various stages of development were included in the studied sample. With the development of prostate cancer, four additional specific plasminogen isoforms are registered in blood plasma; they are characterized by lower molecular weights and higher p I values compared to isoforms found in the control group.
AbstractList Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plasminogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in various stages of development were included in the studied sample. With the development of prostate cancer, four additional specific plasminogen isoforms are registered in blood plasma; they are characterized by lower molecular weights and higher pI values compared to isoforms found in the control group.[PUBLICATION ABSTRACT]
Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plasminogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in various stages of development were included in the studied sample. With the development of prostate cancer, four additional specific plasminogen isoforms are registered in blood plasma; they are characterized by lower molecular weights and higher pI values compared to isoforms found in the control group.
Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plasminogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in various stages of development were included in the studied sample. With the development of prostate cancer, four additional specific plasminogen isoforms are registered in blood plasma; they are characterized by lower molecular weights and higher pI values compared to isoforms found in the control group. DOI: 10.1134/S0006297912090143 Key words: plasminogen isoforms, two-dimensional electrophoresis, MALDI-TOF-MS, prostate cancer
Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plasminogen isoforms were separated and identified in blood plasma. Healthy donors and patients with prostate cancer in various stages of development were included in the studied sample. With the development of prostate cancer, four additional specific plasminogen isoforms are registered in blood plasma; they are characterized by lower molecular weights and higher p I values compared to isoforms found in the control group.
Audience Academic
Author Zimakov, D. V.
Kogan, M. I.
Belova, T. N.
Tarasov, V. A.
Boyko, N. V.
Chibichian, M. B.
Matishov, D. G.
Vodolazhsky, D. I.
Cherkasova, E. N.
Shin, E. F.
Moshkovskii, S. A.
Golikov, A. Yu
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Keywords two-dimensional electrophoresis
MALDI-TOF-MS
prostate cancer
plasminogen isoforms
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Snippet Using affinity chromatography, two-dimensional electrophoresis, and MALDI-TOF mass spectrometry, plasminogen isoforms were separated and identified in blood...
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SubjectTerms Aged
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cancer
Cancer patients
Care and treatment
Developmental stages
Glycoproteins
Humans
Life Sciences
Male
Mass spectrometry
Microbiology
Middle Aged
Oncology, Experimental
Plasma
Plasminogen - analysis
Plasminogen - isolation & purification
Prostate cancer
Prostatic Neoplasms - blood
Proteases
Protein Isoforms - blood
Proteins
Thrombolytic drugs
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Title Separation and study of the range of plasminogen isoforms in patients with prostate cancer
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