Neurotransmitters: emerging targets in cancer

• Published in: Oncogene Vol. 39; no. 3; pp. 503 - 515
• Main Authors: Jiang, Shu-Heng, Hu, Li-Peng, Wang, Xu, Li, Jun, Zhang, Zhi-Gang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.01.2020; Nature Publishing Group
• Subjects: 13/21; 38/39; 42/47; 45/41; 631/67/327; 631/80/86/2363; Angiogenesis; Animals; Antineoplastic Agents - therapeutic use; Antitumor activity; Apoptosis; B cells; Cancer; Carcinogenesis - drug effects; Carcinogenesis - pathology; Cell Biology; Cell proliferation; Development and progression; Disease Models, Animal; Endothelial cells; Human Genetics; Humans; Inflammation; Inflammation - drug therapy; Inflammation - immunology; Inflammation - pathology; Internal Medicine; Medicine; Medicine & Public Health; Mice; Neoplasms - blood supply; Neoplasms - drug therapy; Neoplasms - immunology; Neoplasms - pathology; Neovascularization, Pathologic - drug therapy; Neovascularization, Pathologic - immunology; Neovascularization, Pathologic - pathology; Neurophysiology; Neurotransmitter Agents - antagonists & inhibitors; Neurotransmitter Agents - metabolism; Neurotransmitters; Oncology; Physiological aspects; Receptors, Neurotransmitter - antagonists & inhibitors; Receptors, Neurotransmitter - metabolism; Review Article; Signal transduction; Signal Transduction - drug effects; Tumor Microenvironment - drug effects; Tumor Microenvironment - immunology; Tumorigenesis

Neurotransmitters are conventionally viewed as nerve-secreted substances that mediate the stimulatory or inhibitory neuronal functions through binding to their respective receptors. In the past decades, many novel discoveries come to light elucidating the regulatory roles of neurotransmitters in the...