PERM1—An Emerging Transcriptional Regulator of Mitochondrial Biogenesis: A Systematic Review

• Published in: Genes Vol. 15; no. 10; p. 1305
• Main Authors: Soares Menezes, Eveline, Wu, Zeyu, Renwick, John R. M., Moran-MacDonald, Andres, Gurd, Brendon J.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.10.2024; MDPI
• Subjects: Adipose tissue; Animal models; Animals; Bias; Biosynthesis; Cardiac muscle; Coronary artery disease; Exercise; Genes; Genetic aspects; Heart; Heart diseases; Humans; Identification and classification; Meta-analysis; Mice; Mitochondria; Mitochondria - genetics; Mitochondria - metabolism; Mitochondria, Muscle - genetics; Mitochondria, Muscle - metabolism; Mitochondrial biogenesis; Muscle, Skeletal - metabolism; Musculoskeletal system; Organelle Biogenesis; Oxidative metabolism; Physical fitness; Physiological aspects; Rats; Review; Reviews; Skeletal muscle; Software; Subject heading schemes; Systematic review; Canada; oxidative metabolism; cardiac function; therapeutic target; endurance exercise; disease models; skeletal muscle adaptation

Background/Objectives: This systematic review aims to explore the role of PERM1 across different organisms, tissues, and cellular functions, with a particular focus on its involvement in regulating skeletal muscle mitochondrial biogenesis. Methods: This systematic review follows The PRISMA 2020 Stat...