Heritability of Platelet Responsiveness to Aspirin in Activation Pathways Directly and Indirectly Related to Cyclooxygenase-1

• Published in: Circulation (New York, N.Y.) Vol. 115; no. 19; pp. 2490 - 2496
• Main Authors: Faraday, Nauder, Yanek, Lisa R., Mathias, Rasika, Herrera-Galeano, J. Enrique, Vaidya, Dhananjay, Moy, Taryn F., Fallin, M. Daniele, Wilson, Alexander F., Bray, Paul F., Becker, Lewis C., Becker, Diane M.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 15.05.2007
• Subjects: Adult; African Americans - genetics; Arachidonic Acid - antagonists & inhibitors; Arachidonic Acid - pharmacology; Aspirin - pharmacology; Aspirin - therapeutic use; beta-Thromboglobulin - metabolism; Biological and medical sciences; Blood and lymphatic vessels; Blood coagulation. Blood cells; Blood Platelets - drug effects; Blood Platelets - enzymology; Blood Platelets - physiology; Blood vessels and receptors; Cardiology. Vascular system; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - prevention & control; Coronary Disease - blood; Cyclooxygenase 1 - blood; Cyclooxygenase 1 - physiology; Cyclooxygenase Inhibitors - pharmacology; Cyclooxygenase Inhibitors - therapeutic use; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Drug Resistance - genetics; Dyslipidemias - epidemiology; European Continental Ancestry Group - genetics; Female; Fundamental and applied biological sciences. Psychology; Genetic Heterogeneity; Genetic Predisposition to Disease; Genetic Variation; Humans; Hyperglycemia - epidemiology; Hypertension - epidemiology; Male; Medical sciences; Membrane Proteins - blood; Membrane Proteins - physiology; Middle Aged; Molecular and cellular biology; Phenotype; Platelet; Platelet Activation - drug effects; Platelet Activation - genetics; Platelet Aggregation - drug effects; Platelet Aggregation - genetics; Platelet Aggregation Inhibitors - pharmacology; Platelet Aggregation Inhibitors - therapeutic use; Prospective Studies; Risk Factors; Sex Characteristics; Smoking - epidemiology; Thrombophilia - drug therapy; Thrombophilia - genetics; Thrombosis - prevention & control; Thromboxane B2 - analogs & derivatives; Thromboxane B2 - metabolism; Thromboxane B2 - urine; Vertebrates: cardiovascular system; Prostaglandin-endoperoxide synthase; antiplatelet agents; Enzyme; Cyclooxygenase 1; Enzyme inhibitor; Cardiovascular disease; Acetylsalicylic acid; Antiplatelet agent; platelets; Non steroidal antiinflammatory agent; Platelet; Analgesic; genetics; Antipyretic; aspirin; Oxidoreductases; Salicylates

Background— The inability of aspirin (acetylsalicylic acid [ASA]) to adequately suppress platelet function is associated with future risk of myocardial infarction, stroke, and cardiovascular death. Genetic variation is a proposed but unproved mechanism for insufficient ASA responsiveness. Methods an...