The Impact of FTO Genetic Variants on Obesity and Its Metabolic Consequences is Dependent on Daily Macronutrient Intake

• Published in: Nutrients Vol. 12; no. 11; p. 3255
• Main Authors: Czajkowski, Przemyslaw, Adamska-Patruno, Edyta, Bauer, Witold, Fiedorczuk, Joanna, Krasowska, Urszula, Moroz, Monika, Gorska, Maria, Kretowski, Adam
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.10.2020; MDPI
• Subjects: Adolescent; Adult; Aged; Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics; blood glucose; Body composition; Body fat; Body Mass Index; Carbohydrates; Diabetes; Diet; Diet - adverse effects; Diet - statistics & numerical data; Diet Surveys; dietary fat; Eating - genetics; Energy; Energy intake; European Continental Ancestry Group - genetics; Exercise; Female; Food; Gastrointestinal surgery; Genes; Genetic Predisposition to Disease - genetics; Genotype; Glucose; glucose tolerance tests; Hemoglobin; hips; Humans; insulin; Insulin resistance; Laboratories; lipid content; Lipids; Male; mass; Metabolism; Middle Aged; Nutrients - analysis; Nutrition research; nutrition-genotype interaction; Nutritional Physiological Phenomena - genetics; Obesity; Obesity - genetics; physical activity; Poland; Polymorphism, Single Nucleotide; Proteins; questionnaires; Software; Variance analysis; Vegetarianism; visceral fat; waist circumference; Weight control; Young Adult; Poland; United States > US; Switzerland; dietary carbohydrates; glucose homeostasis; gene-diet interaction; dietary fat; macronutrients; FTO gene; dietary protein; obesity

Numerous studies have identified the various fat mass and obesity-associated (FTO) genetic variants associated with obesity and its metabolic consequences; however, the impact of dietary factors on these associations remains unclear. The aim of this study was to evaluate the association between FTO...