Clinical Review of Juvenile Huntington’s Disease

• Published in: Journal of Huntington's disease Vol. 13; no. 2; pp. 149 - 161
• Main Authors: Oosterloo, Mayke, Touze, Alexiane, Byrne, Lauren M., Achenbach, Jannis, Aksoy, Hande, Coleman, Annabelle, Lammert, Dawn, Nance, Martha, Nopoulos, Peggy, Reilmann, Ralf, Saft, Carsten, Santini, Helen, Squitieri, Ferdinando, Tabrizi, Sarah, Burgunder, Jean-Marc, Quarrell, Oliver
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2024; Sage Publications Ltd; IOS Press
• Subjects: Adolescent; Age of Onset; Ataxia; Attention deficit hyperactivity disorder; Autism; Child; Cognitive ability; Diagnosis; Disease Progression; Dystonia; Epilepsy; Fatty liver; Humans; Huntington Disease - diagnosis; Huntington Disease - genetics; Huntingtons disease; Liver diseases; Polyglutamine; Review; Spasticity; Steatosis; Trinucleotide repeat diseases; Trinucleotide repeats

 Juvenile Huntington’s disease (JHD) is rare. In the first decade of life speech difficulties, rigidity, and dystonia are common clinical motor symptoms, whereas onset in the second decade motor symptoms may sometimes resemble adult-onset Huntington’s disease (AOHD). Cognitive decline is mostly dete...