The role of post-translational modifications in driving abnormal cardiovascular complications at high altitude

• Published in: Frontiers in cardiovascular medicine Vol. 9; p. 886300
• Main Authors: Hou, Jun, Wen, Xudong, Long, Pan, Xiong, Shiqiang, Liu, Hanxiong, Cai, Lin, Deng, Haoyu, Zhang, Zhen
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 14.09.2022
• Subjects: cardiovascular complications adverse events; Cardiovascular Medicine; high-altitude pulmonary edema (HAPE); hypobaric hypoxia; lactylation modification; protein post-translational modifications (PTMs)

The high-altitude environment is characterized by hypobaric hypoxia, low temperatures, low humidity, and high radiation, which is a natural challenge for lowland residents entering. Previous studies have confirmed the acute and chronic effects of high altitude on the cardiovascular systems of lowlan...