Mitochondrial DNA and Inflammation in Alzheimer’s Disease

• Published in: Current Issues in Molecular Biology Vol. 45; no. 11; pp. 8586 - 8606
• Main Authors: Galizzi, Giacoma, Di Carlo, Marta
• Format: Journal Article
• Language: English
• Published: MDPI AG 01.10.2023
• Subjects: Advertising executives; Alzheimer's disease; Development and progression; glia; Inflammation; microglia; mitochondria; Mitochondrial DNA; mitochondrial dysfunction; neurodegeneration; neuroinflammation

Mitochondrial dysfunction and neuroinflammation are implicated in the pathogenesis of most neurodegenerative diseases, such as Alzheimer’s disease (AD). In fact, although a growing number of studies show crosstalk between these two processes, there remain numerous gaps in our knowledge of the mechan...