Predictive Utility of Marketed Volumetric Software Tools in Subjects at Risk for Alzheimer Disease: Do Regions Outside the Hippocampus Matter?

• Published in: American journal of neuroradiology : AJNR Vol. 38; no. 3; pp. 546 - 552
• Main Authors: Tanpitukpongse, T.P., Mazurowski, M.A., Ikhena, J., Petrella, J.R.
• Format: Journal Article
• Language: English
• Published: United States American Society of Neuroradiology 01.03.2017
• Subjects: Adult Brain; Aged; Aged, 80 and over; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - pathology; Alzheimer's disease; Atrophy; Atrophy - diagnostic imaging; Atrophy - pathology; Biomarkers; Brain; Cognitive ability; Cognitive Dysfunction - pathology; Computer programs; Conversion; Demographics; Disease Progression; Editor's Choice; Effectiveness; Female; Health risks; Hippocampus; Hippocampus - diagnostic imaging; Hippocampus - pathology; Humans; Impairment; Logistic Models; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medical imaging; Neurodegenerative diseases; Neuroimaging; Neurology; Patients; Regional analysis; Regression analysis; ROC Curve; Software; Software development tools; Software packages

Alzheimer disease is a prevalent neurodegenerative disease. Computer assessment of brain atrophy patterns can help predict conversion to Alzheimer disease. Our aim was to assess the prognostic efficacy of individual-versus-combined regional volumetrics in 2 commercially available brain volumetric so...