Projection to Latent Spaces Disentangles Pathological Effects on Brain Morphology in the Asymptomatic Phase of Alzheimer's Disease

• Published in: Frontiers in neurology Vol. 11; p. 648
• Main Authors: Casamitjana, Adrià, Petrone, Paula, Molinuevo, José Luis, Gispert, Juan Domingo, Vilaplana, Verónica
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 28.07.2020
• Subjects: Alzheimer's disease; brain morphology; CSF biomarkers; latent model; Neurology; PLS; pre-clinical AD

Alzheimer's disease (AD) continuum is defined as a cascade of several neuropathological processes that can be measured using biomarkers, such as cerebrospinal fluid (CSF) levels of Aβ, p-tau, and t-tau. In parallel, brain anatomy can be characterized through imaging techniques, such as magnetic...