Preparation of New Nitrogen-Bridged Heterocycles. 40. Synthesis of 1,4-Dihydropyrido[2,3-b]indolizin-4-one Derivatives

• Published in: Bulletin of the Chemical Society of Japan Vol. 68; no. 12; pp. 3573 - 3580
• Main Authors: Kakehi, Akikazu, Ito, Suketaka, Hayashi, Shigetoshi, Fujii, Takashi
• Format: Journal Article
• Language: English
• Published: TOKYO The Chemical Society of Japan 01.12.1995; Chemical Soc Japan; Chemical Society of Japan
• Subjects: Chemistry; Chemistry, Multidisciplinary; Physical Sciences; Science & Technology; THIENO<3,2-A>INDOLIZINE; THIENO<2,3-B>INDOLIZINE DERIVATIVES

The title compounds, 1,4-dihydropyrido[2,3-b]indolizin-4-one derivatives, were prepared in moderate to good yields via the N-formylation of some 3-acetyl-2-(alkylamino)indolizines with triethyl orthoformate and acetic anhydride in the presence of zinc chloride followed by the intramolecular dehydrat...