Increased Cerebrospinal Fluid Levels of Soluble Triggering Receptor Expressed on Myeloid Cells 2 and Chitinase-3-Like Protein 1 in Idiopathic Normal-Pressure Hydrocephalus

• Published in: Journal of Alzheimer's disease Vol. 93; no. 4; pp. 1341 - 1354
• Main Authors: Yang, Fuxia, Yang, Lu, Fang, Xuhao, Deng, Yao, Mao, Renling, Yan, Aijuan, Wei, Wenshi
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 13.06.2023
• Subjects: Alzheimer Disease - pathology; Amyloid beta-Peptides - cerebrospinal fluid; Biomarkers - cerebrospinal fluid; Chitinase-3-Like Protein 1; Chitinases; Humans; Hydrocephalus, Normal Pressure - cerebrospinal fluid; Hydrocephalus, Normal Pressure - surgery; Myeloid Cells; Neurodegenerative Diseases; Neuroinflammatory Diseases; tau Proteins - cerebrospinal fluid; Biomarkers; normal pressure hydrocephalus; neuroinflammation; cerebrospinal fluid

Background: Neurodegenerative disease pathology is associated with neuroinflammation, but evidence on idiopathic normal pressure hydrocephalus (iNPH) remains limited and cerebrospinal fluid (CSF) biomarker profiles need to be elucidated. Objective: To investigate whether iNPH pathological mechanisms...