Dual role of cofilin in APP trafficking and amyloid-β clearance

• Published in: The FASEB journal Vol. 33; no. 12; p. 14234
• Main Authors: Liu, Tian, Woo, Jung-A A, Yan, Yan, LePochat, Patrick, Bukhari, Mohammed Zaheen, Kang, David E
• Format: Journal Article
• Language: English
• Published: United States 01.12.2019
• Subjects: Alzheimer Disease - metabolism; Amyloid beta-Peptides - genetics; Amyloid beta-Peptides - metabolism; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Amyloid Precursor Protein Secretases - genetics; Amyloid Precursor Protein Secretases - metabolism; Animals; CHO Cells; Cricetinae; Cricetulus; Gene Expression Regulation - physiology; Gene Knockdown Techniques; Mice; Mice, Inbred Strains; Mice, Transgenic; Microglia - metabolism; Aβ microglia; actin dynamics; endocytosis; amyloid precursor protein

The accumulation of amyloid-β (Aβ) plays a pivotal early event in the pathogenesis of Alzheimer's disease (AD). In the brain, neurons produce Aβ by the proteolytic processing of amyloid precursor protein (APP) through the endocytic pathway, whereas microglia mediate Aβ clearance also endocytic...