Reaction of rat hepatic glucokinase with substrate-related and other alkylating agents

• Published in: European journal of biochemistry Vol. 99; no. 2; pp. 299 - 308
• Main Authors: Connolly, B.A, Trayer, I.P. (Birmingham Univ. (UK). Dept. of Biochemistry)
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.1979
• Subjects: Acetylglucosamine - analogs & derivatives; Acetylglucosamine - chemical synthesis; Affinity Labels; Alkylating Agents - metabolism; Alkylation; Animals; Glucokinase - antagonists & inhibitors; Hydrogen-Ion Concentration; Kinetics; Liver - enzymology; Rats

The reaction of rat hepatic glucokinase with a variety of alkylating agents has been investigated. The substrate‐related alkylating agents N‐bromoacetylglucosamine, N(‐N‐bromoacetyl)glycylglucosamine and N‐(N‐bromoacetyl)‐6‐aminohexanoylglucosamine are all good competitive inhibitors, with respect t...