Multifunctional Hydrophobized Microparticles for Accelerated Wound Healing after Endoscopic Submucosal Dissection
Endoscopic submucosal dissection (ESD) provides strong therapeutic benefits for early gastrointestinal cancer as a minimally invasive treatment. However, there is currently no reliable treatment to prevent scar contracture resulting from ESD which may lead to cicatricial stricture. Herein, a multifu...
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| Published in | Small (Weinheim an der Bergstrasse, Germany) Vol. 15; no. 35; pp. e1901566 - n/a |
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| Main Authors | , , , , , |
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| Language | English |
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01.08.2019
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| Abstract | Endoscopic submucosal dissection (ESD) provides strong therapeutic benefits for early gastrointestinal cancer as a minimally invasive treatment. However, there is currently no reliable treatment to prevent scar contracture resulting from ESD which may lead to cicatricial stricture. Herein, a multifunctional colloidal wound dressing to promote tissue regeneration after ESD is demonstrated. This sprayable wound dressing, composed of hydrophobized microparticles, exhibits the multifunctionality necessary for wound healing including tissue adhesiveness, blood coagulation, re‐epithelialization, angiogenesis, and controlled inflammation based on hydrophobic interaction with biological systems. An in vivo feasibility study using swine gastric ESD models reveals that this colloidal wound dressing suppresses fibrosis and accelerates wound healing. Multifunctional colloidal and sprayable wound dressings have an enormous therapeutic potential for use in a wide range of biomedical applications including accelerated wound healing after ESD, prevention of perforation, and the treatment of inflammatory diseases.
A tissue‐adhesive microparticle‐based wound dressing for promoting wound healing after endoscopic surgery is demonstrated. Sprayable dressing of hydrophobized microparticles exhibits the multifunctionality necessary for wound healing including tissue adhesiveness, blood coagulation, re‐epithelialization, and angiogenesis based on hydrophobic interaction with biological systems. An in vivo feasibility study using swine gastric endoscopic submucosal dissection models reveals suppression of fibrosis and promotion of wound healing. |
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| AbstractList | Endoscopic submucosal dissection (ESD) provides strong therapeutic benefits for early gastrointestinal cancer as a minimally invasive treatment. However, there is currently no reliable treatment to prevent scar contracture resulting from ESD which may lead to cicatricial stricture. Herein, a multifunctional colloidal wound dressing to promote tissue regeneration after ESD is demonstrated. This sprayable wound dressing, composed of hydrophobized microparticles, exhibits the multifunctionality necessary for wound healing including tissue adhesiveness, blood coagulation, re-epithelialization, angiogenesis, and controlled inflammation based on hydrophobic interaction with biological systems. An in vivo feasibility study using swine gastric ESD models reveals that this colloidal wound dressing suppresses fibrosis and accelerates wound healing. Multifunctional colloidal and sprayable wound dressings have an enormous therapeutic potential for use in a wide range of biomedical applications including accelerated wound healing after ESD, prevention of perforation, and the treatment of inflammatory diseases. Abstract Endoscopic submucosal dissection (ESD) provides strong therapeutic benefits for early gastrointestinal cancer as a minimally invasive treatment. However, there is currently no reliable treatment to prevent scar contracture resulting from ESD which may lead to cicatricial stricture. Herein, a multifunctional colloidal wound dressing to promote tissue regeneration after ESD is demonstrated. This sprayable wound dressing, composed of hydrophobized microparticles, exhibits the multifunctionality necessary for wound healing including tissue adhesiveness, blood coagulation, re‐epithelialization, angiogenesis, and controlled inflammation based on hydrophobic interaction with biological systems. An in vivo feasibility study using swine gastric ESD models reveals that this colloidal wound dressing suppresses fibrosis and accelerates wound healing. Multifunctional colloidal and sprayable wound dressings have an enormous therapeutic potential for use in a wide range of biomedical applications including accelerated wound healing after ESD, prevention of perforation, and the treatment of inflammatory diseases. Endoscopic submucosal dissection (ESD) provides strong therapeutic benefits for early gastrointestinal cancer as a minimally invasive treatment. However, there is currently no reliable treatment to prevent scar contracture resulting from ESD which may lead to cicatricial stricture. Herein, a multifunctional colloidal wound dressing to promote tissue regeneration after ESD is demonstrated. This sprayable wound dressing, composed of hydrophobized microparticles, exhibits the multifunctionality necessary for wound healing including tissue adhesiveness, blood coagulation, re‐epithelialization, angiogenesis, and controlled inflammation based on hydrophobic interaction with biological systems. An in vivo feasibility study using swine gastric ESD models reveals that this colloidal wound dressing suppresses fibrosis and accelerates wound healing. Multifunctional colloidal and sprayable wound dressings have an enormous therapeutic potential for use in a wide range of biomedical applications including accelerated wound healing after ESD, prevention of perforation, and the treatment of inflammatory diseases. A tissue‐adhesive microparticle‐based wound dressing for promoting wound healing after endoscopic surgery is demonstrated. Sprayable dressing of hydrophobized microparticles exhibits the multifunctionality necessary for wound healing including tissue adhesiveness, blood coagulation, re‐epithelialization, and angiogenesis based on hydrophobic interaction with biological systems. An in vivo feasibility study using swine gastric endoscopic submucosal dissection models reveals suppression of fibrosis and promotion of wound healing. |
| Author | Nishiguchi, Akihiro Taguchi, Tetsushi Sasaki, Fumisato Maeda, Hidehito Kabayama, Masayuki Ido, Akio |
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| Cites_doi | 10.1055/s-0032-1310107 10.1016/S0140-6736(07)60751-X 10.1007/s10620-013-2958-5 10.1126/science.aad9272 10.1038/nature12806 10.1111/apt.13254 10.1038/nature05968 10.1016/j.gie.2014.09.038 10.1016/j.progpolymsci.2014.02.001 10.1016/j.gie.2008.04.022 10.1007/s10120-006-0408-1 10.1007/s11095-007-9475-1 10.1097/MD.0000000000000373 10.1002/adfm.201702424 10.1039/C6BM00829A 10.1016/j.biomaterials.2015.06.003 10.1053/j.gastro.2012.04.050 10.1038/nature07039 10.1155/2016/1457357 10.1002/mabi.201600349 10.1002/anie.201401043 10.1038/nri1372 10.1016/j.colsurfb.2012.06.033 10.4318/tjg.2013.0522 10.1016/j.biomaterials.2010.12.033 10.1002/ijc.29210 10.1016/j.gie.2009.12.024 10.1002/adma.201602606 10.1016/S0378-5173(03)00386-7 10.1016/j.gie.2009.04.044 10.1016/j.ijpharm.2010.10.012 10.1097/MCG.0b013e3181f39f4e 10.1038/nrm809 10.1055/s-0032-1325739 10.1007/BF02087708 10.1166/jbn.2016.2210 |
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| References_xml | – volume: 70 start-page: 860 year: 2009 publication-title: Gastrointest. Endosc. – volume: 59 start-page: 658 year: 2014 publication-title: Dig. Dis. Sci. – volume: 94 year: 2015 publication-title: Medicine – volume: 12 start-page: 128 year: 2016 publication-title: J. Biomed. Nanotechnol. – volume: 69 start-page: 289 year: 2009 publication-title: Gastrointest. Endosc. – volume: 63 start-page: 14 year: 2015 publication-title: Biomaterials – volume: 505 start-page: 382 year: 2014 publication-title: Nature – volume: 45 start-page: 222 year: 2011 publication-title: J. Clin. Gastroenterol. – volume: 369 start-page: 1641 year: 2007 publication-title: Lancet – volume: 53 start-page: 6369 year: 2014 publication-title: Angew. Chem., Int. Ed. – volume: 13 start-page: 131 year: 2011 publication-title: Rev. Urol. – volume: 25 start-page: 999 year: 2008 publication-title: Pharm. Res. – volume: 2016 start-page: 1 year: 2016 publication-title: Gastroenterol. Res. Pract. – volume: 453 start-page: 314 year: 2008 publication-title: Nature – volume: 27 start-page: 1702424 year: 2017 publication-title: Adv. Funct. Mater. – volume: 352 start-page: 366 year: 2016 publication-title: Science – volume: 42 start-page: 20 year: 2015 publication-title: Aliment. Pharmacol. Ther. – volume: 143 start-page: 582 year: 2012 publication-title: Gastroenterology – volume: 5 start-page: 982 year: 2017 publication-title: Biomater. Sci. – volume: 10 start-page: 1 year: 2007 publication-title: Gastric Cancer – volume: 44 start-page: 1007 year: 2012 publication-title: Endoscopy – volume: 39 start-page: 2671 year: 1994 publication-title: Dig. Dis. Sci. – volume: 3 start-page: 349 year: 2002 publication-title: Nat. Rev. Mol. Cell Biol. – volume: 264 start-page: 45 year: 2003 publication-title: Int. J. Pharm. – volume: 403 start-page: 192 year: 2011 publication-title: Int. J. Pharm. – volume: 28 start-page: 8675 year: 2016 publication-title: Adv. Mater. – volume: 136 start-page: E359 year: 2015 publication-title: Int. J. Cancer – volume: 81 start-page: 989 year: 2015 publication-title: Gastrointest. Endosc. – volume: 17 start-page: 1600349 year: 2017 publication-title: Macromol. Biosci. – volume: 32 start-page: 3351 year: 2011 publication-title: Biomaterials – volume: 44 start-page: E414 year: 2012 publication-title: Endoscopy – volume: 71 start-page: 856 year: 2010 publication-title: Gastrointest. Endosc. – volume: 448 start-page: 338 year: 2007 publication-title: Nature – volume: 24 start-page: 161 year: 2013 publication-title: Turk. J. Gastroenterol. – volume: 101 start-page: 223 year: 2013 publication-title: Colloids Surf., B – volume: 39 start-page: 1375 year: 2014 publication-title: Prog. Polym. Sci. – volume: 4 start-page: 469 year: 2004 publication-title: Nat. Rev. Immunol. – ident: e_1_2_7_9_1 doi: 10.1055/s-0032-1310107 – ident: e_1_2_7_37_1 doi: 10.1016/S0140-6736(07)60751-X – ident: e_1_2_7_8_1 doi: 10.1007/s10620-013-2958-5 – ident: e_1_2_7_32_1 doi: 10.1126/science.aad9272 – ident: e_1_2_7_26_1 doi: 10.1038/nature12806 – ident: e_1_2_7_17_1 doi: 10.1111/apt.13254 – ident: e_1_2_7_34_1 doi: 10.1038/nature05968 – ident: e_1_2_7_10_1 doi: 10.1016/j.gie.2014.09.038 – ident: e_1_2_7_35_1 doi: 10.1016/j.progpolymsci.2014.02.001 – ident: e_1_2_7_13_1 doi: 10.1016/j.gie.2008.04.022 – ident: e_1_2_7_2_1 doi: 10.1007/s10120-006-0408-1 – ident: e_1_2_7_19_1 doi: 10.1007/s11095-007-9475-1 – ident: e_1_2_7_4_1 doi: 10.1097/MD.0000000000000373 – ident: e_1_2_7_12_1 doi: 10.1002/adfm.201702424 – ident: e_1_2_7_22_1 doi: 10.1039/C6BM00829A – ident: e_1_2_7_24_1 doi: 10.1016/j.biomaterials.2015.06.003 – ident: e_1_2_7_16_1 doi: 10.1053/j.gastro.2012.04.050 – ident: e_1_2_7_6_1 doi: 10.1038/nature07039 – ident: e_1_2_7_14_1 doi: 10.1155/2016/1457357 – volume: 13 start-page: 131 year: 2011 ident: e_1_2_7_29_1 publication-title: Rev. Urol. contributor: fullname: Galanakis I. – ident: e_1_2_7_25_1 doi: 10.1002/mabi.201600349 – ident: e_1_2_7_27_1 doi: 10.1002/anie.201401043 – ident: e_1_2_7_18_1 doi: 10.1038/nri1372 – ident: e_1_2_7_30_1 doi: 10.1016/j.colsurfb.2012.06.033 – ident: e_1_2_7_33_1 doi: 10.4318/tjg.2013.0522 – ident: e_1_2_7_31_1 doi: 10.1016/j.biomaterials.2010.12.033 – ident: e_1_2_7_1_1 doi: 10.1002/ijc.29210 – ident: e_1_2_7_28_1 doi: 10.1016/j.gie.2009.12.024 – ident: e_1_2_7_36_1 doi: 10.1002/adma.201602606 – ident: e_1_2_7_20_1 doi: 10.1016/S0378-5173(03)00386-7 – ident: e_1_2_7_5_1 doi: 10.1016/j.gie.2009.04.044 – ident: e_1_2_7_21_1 doi: 10.1016/j.ijpharm.2010.10.012 – ident: e_1_2_7_7_1 doi: 10.1097/MCG.0b013e3181f39f4e – ident: e_1_2_7_3_1 doi: 10.1038/nrm809 – ident: e_1_2_7_11_1 doi: 10.1055/s-0032-1325739 – ident: e_1_2_7_15_1 doi: 10.1007/BF02087708 – ident: e_1_2_7_23_1 doi: 10.1166/jbn.2016.2210 |
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| SubjectTerms | Biomedical materials Blood coagulation Colloids Dissection endoscopic submucosal dissection Endoscopy Feasibility studies Fibrosis Hydrophobicity In vivo methods and tests Microparticles Nanotechnology nano‐bio interface Perforation Regeneration Swine tissue adhesion Tissue engineering Wound healing |
| Title | Multifunctional Hydrophobized Microparticles for Accelerated Wound Healing after Endoscopic Submucosal Dissection |
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