Multifunctional Hydrophobized Microparticles for Accelerated Wound Healing after Endoscopic Submucosal Dissection

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 15; no. 35; pp. e1901566 - n/a
• Main Authors: Nishiguchi, Akihiro, Sasaki, Fumisato, Maeda, Hidehito, Kabayama, Masayuki, Ido, Akio, Taguchi, Tetsushi
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.08.2019
• Subjects: Biomedical materials; Blood coagulation; Colloids; Dissection; endoscopic submucosal dissection; Endoscopy; Feasibility studies; Fibrosis; Hydrophobicity; In vivo methods and tests; Microparticles; Nanotechnology; nano‐bio interface; Perforation; Regeneration; Swine; tissue adhesion; Tissue engineering; Wound healing; tissue adhesion; endoscopic submucosal dissection; microparticles; wound healing; nano-bio interface
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.201901566

Endoscopic submucosal dissection (ESD) provides strong therapeutic benefits for early gastrointestinal cancer as a minimally invasive treatment. However, there is currently no reliable treatment to prevent scar contracture resulting from ESD which may lead to cicatricial stricture. Herein, a multifunctional colloidal wound dressing to promote tissue regeneration after ESD is demonstrated. This sprayable wound dressing, composed of hydrophobized microparticles, exhibits the multifunctionality necessary for wound healing including tissue adhesiveness, blood coagulation, re‐epithelialization, angiogenesis, and controlled inflammation based on hydrophobic interaction with biological systems. An in vivo feasibility study using swine gastric ESD models reveals that this colloidal wound dressing suppresses fibrosis and accelerates wound healing. Multifunctional colloidal and sprayable wound dressings have an enormous therapeutic potential for use in a wide range of biomedical applications including accelerated wound healing after ESD, prevention of perforation, and the treatment of inflammatory diseases. A tissue‐adhesive microparticle‐based wound dressing for promoting wound healing after endoscopic surgery is demonstrated. Sprayable dressing of hydrophobized microparticles exhibits the multifunctionality necessary for wound healing including tissue adhesiveness, blood coagulation, re‐epithelialization, and angiogenesis based on hydrophobic interaction with biological systems. An in vivo feasibility study using swine gastric endoscopic submucosal dissection models reveals suppression of fibrosis and promotion of wound healing.