Osteogenic Capability of Vaterite‐Coated Nonwoven Polycaprolactone Scaffolds for In Vivo Bone Tissue Regeneration

• Published in: Macromolecular bioscience Vol. 21; no. 12; pp. e2100266 - n/a
• Main Authors: Saveleva, Mariia S., Ivanov, Alexey N., Chibrikova, Julia A., Abalymov, Anatolii A., Surmeneva, Maria A., Surmenev, Roman A., Parakhonskiy, Bogdan V., Lomova, Maria V., Skirtach, Andre G., Norkin, Igor A.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.12.2021
• Subjects: Alkaline phosphatase; Angiogenesis; Animals; Biomedical materials; Biomimetics; Bone growth; Bone implants; bone repair; Bone Substitutes - chemistry; Bone turnover; bone turnover markers; Bones; Calcium carbonate; Coated Materials, Biocompatible - chemistry; Femur; Femur - injuries; Femur - metabolism; Immobilization; Implantation; Male; Orthopedics; Osseointegration; Osteocalcin; Osteoconduction; Osteogenesis; Polycaprolactone; Polyesters - chemistry; Rats; Regeneration; Regeneration (physiology); Repair; scaffold; Scaffolds; Tissue engineering; Tissue Scaffolds - chemistry; Transplants & implants; vaterite; vaterite; implantation; osteogenesis; bone turnover markers; scaffold; bone repair

In current orthopedic practice, bone implants used to‐date often exhibit poor osteointegration, impaired osteogenesis, and, eventually, implant failure. Actively pursued strategies for tissue engineering could overcome these shortcomings by developing new hybrid materials with bioinspired structure...