Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 51; no. 4; p. 418
• Main Authors: de Magistris, Laura, Familiari, Valeria, Pascotto, Antonio, Sapone, Anna, Frolli, Alessandro, Iardino, Patrizia, Carteni, Maria, De Rosa, Mario, Francavilla, Ruggiero, Riegler, Gabriele, Militerni, Roberto, Bravaccio, Carmela
• Format: Journal Article
• Language: English
• Published: United States 01.10.2010
• Subjects: Abdominal Pain - epidemiology; Analysis of Variance; Child; Child Development Disorders, Pervasive - epidemiology; Child Development Disorders, Pervasive - metabolism; Comorbidity; Constipation - epidemiology; Diarrhea - epidemiology; Enzyme-Linked Immunosorbent Assay; Family; Feces; Female; Humans; Inflammation - epidemiology; Intestinal Diseases - epidemiology; Intestinal Diseases - metabolism; Intestinal Mucosa - metabolism; Intestinal Mucosa - physiopathology; Italy - epidemiology; Leukocyte L1 Antigen Complex - metabolism; Male; Permeability; Italy

Intestinal permeability (IPT) was investigated in patients with autism as well as in their first-degree relatives to investigate leaky gut hypothesis. Faecal calprotectin (FC) was also measured in patients with autism, either with or without gastrointestinal symptoms, and in their first-degree relat...