Recent Advances on the Selection Methods of DNA‐Encoded Libraries

• Published in: Chembiochem : a European journal of chemical biology Vol. 22; no. 14; pp. 2384 - 2397
• Main Authors: Huang, Yiran, Li, Xiaoyu
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 15.07.2021
• Subjects: Binders; Binding; Combinatorial library; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA-encoded library; Drug Discovery; Gene Library; High throughput screening; Humans; Libraries; Ligand discovery; Ligands; Pharmaceutical industry; Proteins; Proteins - chemistry; Proteins - metabolism; Small Molecule Libraries - chemistry; Small Molecule Libraries - metabolism; Solid phases; High throughput screening; Ligand discovery; DNA-encoded library; Drug discovery; Combinatorial library

DNA‐encoded libraries (DEL) have come of age and become a major technology platform for ligand discovery in both academia and the pharmaceutical industry. Technological maturation in the past two decades and the recent explosive developments of DEL‐compatible chemistries have greatly improved the ch...