Synergistic Reinforcing of Immunogenic Cell Death and Transforming Tumor‐Associated Macrophages Via a Multifunctional Cascade Bioreactor for Optimizing Cancer Immunotherapy

• Published in: Advanced materials (Weinheim) Vol. 34; no. 51; pp. e2207593 - n/a
• Main Authors: Huang, Cong, Lin, Bingquan, Chen, Chuyao, Wang, Huaiming, Lin, Xiaosheng, Liu, Jiamin, Ren, Qingfan, Tao, Jia, Zhao, Peng, Xu, Yikai
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.12.2022
• Subjects: Apoptosis; Bioreactors; Calcium ions; calcium‐ion overload; Cell death; Cell Line, Tumor; Copper sulfides; Damage patterns; damage‐associated molecular patterns; Humans; Immunogenic Cell Death; Immunotherapy; Immunotherapy - methods; Irradiation; Macrophages; Manganese Compounds; Manganese dioxide; Materials science; Mitochondria; Mitochondrial DNA; Nanocomposites; Nanoparticles; Near infrared radiation; Neoplasms - therapy; Oxides - pharmacology; Photochemotherapy - methods; Photodynamic therapy; Tumor Microenvironment; Tumor-Associated Macrophages; calcium-ion overload; damage-associated molecular patterns; photodynamic therapy; immunotherapy; tumor-associated macrophages

Immunogenic cell death (ICD) has aroused widespread attention because it can reconstruct a tumor microenvironment and activate antitumor immunity. This study proposes a two‐way enhancement of ICD based on a CaO2@CuS–MnO2@HA (CCMH) nanocomposite to overcome the insufficient damage‐associated molecula...