Design of Chiral Bifunctional Dialkyl Sulfide Catalysts for Regio‐, Diastereo‐, and Enantioselective Bromolactonization

• Published in: Chemistry : a European journal Vol. 24; no. 63; pp. 16747 - 16752
• Main Authors: Nishiyori, Ryuichi, Tsuchihashi, Ayano, Mochizuki, Ayaka, Kaneko, Kazuma, Yamanaka, Masahiro, Shirakawa, Seiji
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 13.11.2018; Wiley Subscription Services, Inc
• Subjects: asymmetric synthesis; Catalysis; Catalysts; Chemistry; Chemistry, Multidisciplinary; Dialkyl sulfides; Enantiomers; lactonizations; organocatalysis; Physical Sciences; Science & Technology; Sulfide; Sulfides; transition states; Urea; Ureas; ORGANIC-SYNTHESIS; SULFUR YLIDES; HYDRANGEAE DULCIS FOLIUM; PHASE-TRANSFER CATALYST; OLEFINIC 1,3-DIOLS; lactonizations; organocatalysis; ALKENES; asymmetric synthesis; transition states; ASYMMETRIC EPOXIDATION; SULFONIUM YLIDES; YLIDE-MEDIATED EPOXIDATION; sulfides; REGIOSELECTIVE BROMOCYCLIZATION

Although a wide variety of chiral organocatalysts have been developed for asymmetric transformations, effective chiral dialkyl sulfide organocatalysts remain relatively rare and under‐developed, despite the potential utility of dialkyl sulfide catalysts. Herein, we report the development of chiral b...