Enantioselective Hydroxylation of Dihydrosilanes to Si‐Chiral Silanols Catalyzed by In Situ Generated Copper(II) Species

• Published in: Angewandte Chemie International Edition Vol. 61; no. 32; pp. e202205743 - n/a
• Main Authors: Yang, Wu, Liu, Lin, Guo, Jiandong, Wang, Shou‐Guo, Zhang, Jia‐Yong, Fan, Li‐Wen, Tian, Yu, Wang, Li‐Lei, Luan, Cheng, Li, Zhong‐Liang, He, Chuan, Wang, Xiaotai, Gu, Qiang‐Shuai, Liu, Xin‐Yuan
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 08.08.2022; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Asymmetric Catalysis; Catalysts; Chemistry; Chemistry, Multidisciplinary; Copper; Electron transfer; Enantiomers; Functional groups; Hydroxylation; Metathesis; Oxidants; Oxidizing agents; Physical Sciences; Science & Technology; Silanols; Silicon compounds; Single-Electron Transfer (SET) Oxidation; Species; Single-Electron Transfer (SET) Oxidation; ASYMMETRIC-SYNTHESIS; Metathesis; CLASSIFICATION; C-H SILYLATION; SILICON-STEREOGENIC SILANES; COORDINATION-COMPOUNDS; ALKENES; Asymmetric Catalysis; Silanols; KINETIC RESOLUTION; Copper; ACCESS; STRUCTURAL DATA; 1,2-DIFUNCTIONALIZATION; silanols; single-electron transfer (SET) oxidation; copper; asymmetric catalysis; metathesis

Catalytic enantioselective hydroxylation of prochiral dihydrosilanes with water is expected to be a highly efficient way to access Si‐chiral silanols, yet has remained unknown up to date. Herein, we describe a strategy for realizing this reaction: using an alkyl bromide as a single‐electron transfer...