μ‐Opioid receptors in primary sensory neurons are essential for opioid analgesic effect on acute and inflammatory pain and opioid‐induced hyperalgesia

• Published in: The Journal of physiology Vol. 597; no. 6; pp. 1661 - 1675
• Main Authors: Sun, Jie, Chen, Shao‐Rui, Chen, Hong, Pan, Hui‐Lin
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.03.2019; John Wiley and Sons Inc
• Subjects: Analgesia; Analgesics; Capsaicin receptors; Dorsal root ganglia; fentanyl; Hyperalgesia; Immunoblotting; Inflammation; Labeling; Morphine; Narcotics; Neuroscience; opiate; opioid analgesic tolerance; Opioid receptors; Pain; Pain perception; Potentiation; presynaptic inhibition; Research Paper; Sensory neurons; Sodium channels (voltage-gated); Spinal cord; synaptic transmission; TRPV1; opioid analgesic tolerance; presynaptic inhibition; synaptic transmission; TRPV1; fentanyl; opiate

Key points μ‐Opioid receptors (MORs) are expressed peripherally and centrally, but the loci of MORs responsible for clinically relevant opioid analgesia are uncertain. Crossing Oprm1flox/flox and AdvillinCre/+ mice completely ablates MORs in dorsal root ganglion neurons and reduces the MOR expressio...