Photothermally Triggered Copper Payload Release for Cuproptosis‐Promoted Cancer Synergistic Therapy

• Published in: Angewandte Chemie International Edition Vol. 62; no. 12; pp. e202213922 - n/a
• Main Authors: Zhou, Jie, Yu, Qiao, Song, Juan, Li, Shan, Li, Xiang‐Ling, Kang, Bin K., Chen, Hong‐Yuan, Xu, Jing‐Juan
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 13.03.2023
• Edition: International ed. in English
• Subjects: Antineoplastic Agents - pharmacology; Apoptosis; Cancer; Cell death; Cell Line, Tumor; Copper; Copper - pharmacology; Copper Delivery; Cuproptosis; Cytotoxicity; Disulfiram; Disulfiram - pharmacology; Disulfiram - therapeutic use; Ditiocarb; Gold; Growth inhibition; Humans; Mitochondria; Nanostructures; Neoplasms - drug therapy; Photothermally Triggered Release; Protein interaction; Synergistic Therapy; Therapy; Tumor cells; Tumors; Photothermally Triggered Release; Nanostructures; Copper Delivery; Cuproptosis; Synergistic Therapy

Cuproptosis is a new form of programmed cell death and exhibits enormous potential in cancer treatment. However, reducing the undesirable Cu ion release in normal tissue and maximizing the copper‐induced therapeutic effect in cancer sites are two main challenges. In this study, we constructed a phot...