Newly developed strategies for improving sensitivity to radiation by targeting signal pathways in cancer therapy

• Published in: Cancer science Vol. 104; no. 11; pp. 1401 - 1410
• Main Authors: Ding, Miao, Zhang, Erlong, He, Rong, Wang, Xingyong
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.11.2013
• Subjects: Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis - drug effects; Drug Synergism; Humans; Molecular Targeted Therapy; Neoplasms - metabolism; Neoplasms - pathology; Neoplasms - radiotherapy; Radiation Tolerance - drug effects; Radiation-Sensitizing Agents - pharmacology; Radiation-Sensitizing Agents - therapeutic use; Review; Signal Transduction - drug effects

Inherent and acquired resistance of cancer cells is increasingly recognized as a significant impediment to effective radiation cancer treatment. As important intracellular factors, aberrant tumor transmembrane signal transduction pathways, which include the prosurvival cascades (PI3K/Akt, MAPK/ERK a...