Size, Shape, and Protein Corona Determine Cellular Uptake and Removal Mechanisms of Gold Nanoparticles

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 14; no. 42; pp. e1801451 - n/a
• Main Authors: Ding, Lin, Yao, Chenjie, Yin, Xiaofeng, Li, Chenchen, Huang, Yanan, Wu, Min, Wang, Bin, Guo, Xiaoya, Wang, Yanli, Wu, Minghong
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.10.2018
• Subjects: cellular uptake; Endocytosis; Gold; gold nanoparticles; mechanisms; Nanoparticles; Nanotechnology; Proteins; removal; Toxicology; removal; gold nanoparticles; mechanisms; cellular uptake

Size, shape, and protein corona play a key role in cellular uptake and removal mechanisms of gold nanoparticles (Au NPs). The 15 nm nanoparticles (NP1), the 45 nm nanoparticles (NP2), and the rod‐shaped nanoparticles (NR) enter into cells via a receptor‐mediated endocytosis (RME) pathway. The star‐s...