NIR‐II Ratiometric Chemiluminescent/Fluorescent Reporters for Real‐Time Monitoring and Evaluating Cancer Photodynamic Therapy Efficacy

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 18; no. 41; pp. e2202551 - n/a
• Main Authors: Su, Lichao, Chen, Yiming, Huo, Hongqi, Liao, Naishun, Wu, Ying, Ge, Xiaoguang, Guo, Zhiyong, Chen, Zhongxiang, Zhang, Xuan, Song, Jibin
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.10.2022
• Subjects: Cancer; Cell Line, Tumor; Chemiluminescence; Effectiveness; Fluorescence; Micelles; Monitoring; Nanoparticles; Nanotechnology; Near infrared radiation; Neoplasms - drug therapy; Oxygen consumption; Photochemotherapy - methods; Photodynamic therapy; Photosensitizing Agents - pharmacology; Photosensitizing Agents - therapeutic use; ratiometric imaging; singlet molecular oxygen; Singlet Oxygen; Thiophenes; singlet molecular oxygen; fluorescence; ratiometric imaging; chemiluminescence; photodynamic therapy

The development of probes for early monitoring tumor therapy response may greatly benefit the promotion of photodynamic therapy (PDT) efficacy. Singlet oxygen (1O2) generation is a typical indicator for evaluating PDT efficacy in cancer. However, most existing probes cannot quantitatively detect 1O2...