Lipid and Corticosteroid Biomarkers Under the Influence of Bisphosphonates

• Published in: Drug testing and analysis Vol. 17; no. 7; pp. 1107 - 1117
• Main Authors: Tou, Kathy, Cawley, Adam, Noble, Glenys, Loy, Jaymie, Bishop, David, Keledjian, John, Sornalingam, Kireesan, Richards, Stacey, Fu, Shanlin
• Format: Journal Article
• Language: English
• Published: England 01.07.2025
• Subjects: Adrenal Cortex Hormones - blood; Animals; anti‐doping; biomarkers; Biomarkers - blood; bisphosphonates; Bone Density Conservation Agents - administration & dosage; Bone Density Conservation Agents - blood; Bone Density Conservation Agents - pharmacokinetics; Chromatography, Liquid - methods; Diphosphonates - administration & dosage; Diphosphonates - blood; Diphosphonates - pharmacokinetics; Doping in Sports; Horses - blood; Imidazoles - administration & dosage; Imidazoles - blood; Imidazoles - pharmacokinetics; lipids; Lipids - blood; Male; plasma; Solid Phase Extraction - methods; Substance Abuse Detection - methods; Substance Abuse Detection - veterinary; Tandem Mass Spectrometry - methods; Tandem Mass Spectrometry - veterinary; Zoledronic Acid; lipids; bisphosphonates; plasma; biomarkers; anti‐doping

ABSTRACT Detecting the use of bisphosphonates (BPs) in equine athletes is of interest to regulators and laboratories due to the threat to welfare issues for the potential to provide analgesic effects and manipulating bone structure. The detection of BPs in biological matrices is challenging due to e...