HDL (High-Density Lipoprotein) and ApoA-1 (Apolipoprotein A-1) Potentially Modulate Pancreatic α-Cell Glucagon Secretion

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 40; no. 12; pp. 2941 - 2952
• Main Authors: Mancuso, Elettra, Mannino, Gaia Chiara, Fuoco, Anastasia, Leo, Antonio, Citraro, Rita, Averta, Carolina, Spiga, Rosangela, Russo, Emilio, De Sarro, Giovambattista, Andreozzi, Francesco, Sesti, Giorgio
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.12.2020
• Subjects: Adult; Animals; Apolipoprotein A-I - blood; Apolipoprotein A-I - pharmacology; Cell Line; Female; Forkhead Box Protein O1 - metabolism; Glucagon - blood; Glucagon-Secreting Cells - drug effects; Glucagon-Secreting Cells - metabolism; Glucose Tolerance Test; Humans; Italy; Lipoproteins, HDL - blood; Lipoproteins, HDL - pharmacology; Male; Mice, Inbred ICR; Middle Aged; Phosphatidylinositol 3-Kinase - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Scavenger Receptors, Class B - metabolism; Secretory Pathway; Signal Transduction; Time Factors; Italy; blood glucose; type 2; cholesterol, HDL; glucagon; diabetes mellitus; apolipoprotein A-I; glucagon-secreting cells

OBJECTIVE:Subjects with low levels of HDL (high-density lipoprotein) and ApoA-1 have increased risk to develop type 2 diabetes. HDL levels are an independent predictor of β-cell function and positively modulate it. Type 2 diabetes is characterized by defects in both β and α-cell function, but the ef...