Hypoxia‐Responsive Photosensitizer Targeting Dual Organelles for Photodynamic Therapy of Tumors

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 19; no. 1; pp. e2205440 - n/a
• Main Authors: Tang, Yuqi, Wang, Xing, Zhu, Guanqun, Liu, Zhiyang, Chen, Xu‐Man, Bisoyi, Hari Krishna, Chen, Xiao, Chen, Xiaofei, Xu, Yiyi, Li, Juping, Li, Quan
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.01.2023
• Subjects: aggregation‐induced emission; Fluorescence; fluorescence on and off; Humans; Hypoxia; hypoxia‐responsive; Lipids; Lysosomes; Nanotechnology; Neoplasms - drug therapy; Neoplasms - pathology; Organelles; Photochemotherapy; Photodynamic therapy; Photosensitizing Agents - pharmacology; Photosensitizing Agents - therapeutic use; Tumors; aggregation-induced emission; fluorescence on and off; tumors; hypoxia-responsive; photodynamic therapy

Developing safe and precise image‐guided photodynamic therapy is a challenge. In this study, the hypoxic properties of solid tumors are exploited to construct a hypoxia‐responsive photosensitizer, TPA‐Azo. Introducing the azo group into the photosensitizer TPA‐BN with aggregation‐induced emission qu...