A Supramolecular Antidote to Macromolecular Toxins Prepared through Coassembly of Macrocyclic Amphiphiles

• Published in: Advanced materials (Weinheim) Vol. 33; no. 40; pp. e2104310 - n/a
• Main Authors: Pan, Yu‐Chen, Yue, Yu‐Xin, Hu, Xin‐Yue, Li, Hua‐Bin, Guo, Dong‐Sheng
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.10.2021
• Subjects: Animals; Antidotes; Antidotes - chemistry; Antidotes - metabolism; Antidotes - pharmacology; Antimicrobial Cationic Peptides - chemistry; Antimicrobial Cationic Peptides - pharmacology; Binding sites; Biological activity; Calixarenes; Cell Membrane - chemistry; Cell membranes; Cell Survival - drug effects; Cyclodextrins; Cyclodextrins - chemistry; detoxification; Emergency medical services; HEK293 Cells; Hemolysis - drug effects; heteromultivalent recognition; Humans; Liver - drug effects; Liver - pathology; macrocyclic amphiphiles; Macromolecular Substances - chemistry; Macromolecular Substances - metabolism; macromolecular toxins; Macromolecules; Materials science; Melitten - chemistry; Melitten - metabolism; Melitten - pharmacology; Mice; Organs; Poisoning; Recognition; Spider Venoms - chemistry; Spider Venoms - pharmacology; therapeutic materials; Toxicity; Toxins; heteromultivalent recognition; macrocyclic amphiphiles; therapeutic materials; detoxification; macromolecular toxins

Poisoning is a leading cause of admission to medical emergency departments and intensive care units. Supramolecular detoxification, which involves injecting supramolecular receptors that bind with toxins to suppress their biological activity, is an emerging strategy for poisoning treatment; it has f...