The influence of adrenergic stimulation on sex differences in left ventricular twist mechanics

• Published in: The Journal of physiology Vol. 595; no. 12; pp. 3973 - 3985
• Main Authors: Williams, Alexandra M., Shave, Rob E., Cheyne, William S., Eves, Neil D.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 15.06.2017; John Wiley and Sons Inc
• Subjects: Adrenal glands; Adrenergic Agents - pharmacology; Adrenergic receptors; Adult; Autonomic nervous system; Blood pressure; Blood Pressure - drug effects; Echocardiography; Echocardiography - methods; Exercise - physiology; Female; Females; Gender aspects; Gender differences; Hand Strength - physiology; Heart; Heart - drug effects; Heart diseases; Heart rate; Heart Rate - drug effects; Heart Ventricles - drug effects; Heart Ventricles - physiopathology; Hemodynamics; Hemodynamics - drug effects; Humans; Ischemia; left ventricular mechanics; Male; Males; Mechanics; Myocardial Contraction - drug effects; Physical training; Physiology; Polyetherimides; Regulation of Contractile Function in Health and Disease; Research Paper; Rest - physiology; Revisions; Rotation; Sex; Sex Characteristics; Sex differences; Stimulation; Stress (physiology); Stroke; Stroke volume; Stroke Volume - drug effects; Structure-function relationships; Velocity; Ventricle; Ventricular Function, Left - drug effects; Ventricular Function, Left - physiology; Young Adult; left ventricular mechanics; echocardiography; sex

Key points Sex differences in left ventricular (LV) mechanics occur during acute physiological challenges; however, it is unknown whether sex differences in LV mechanics are fundamentally regulated by differences in adrenergic control. Using two‐dimensional echocardiography and speckle tracking anal...