A Nuclear‐Targeted AIE Photosensitizer for Enzyme Inhibition and Photosensitization in Cancer Cell Ablation

• Published in: Angewandte Chemie International Edition Vol. 61; no. 15; pp. e202114600 - n/a
• Main Authors: Wang, Kang‐Nan, Liu, Liu‐Yi, Mao, Duo, Hou, Ming‐Xuan, Tan, Cai‐Ping, Mao, Zong‐Wan, Liu, Bin
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 04.04.2022
• Edition: International ed. in English
• Subjects: Ablation; Cancer; Cell cycle; Cell Cycle Checkpoints; Cell proliferation; Drug Delivery Systems; Histone Deacetylase Inhibition; Histones; Humans; Neoplasms - drug therapy; Nuclear Targeting; Nuclei (cytology); Nucleic Acid Damage; Nucleic acids; Photochemotherapy; Photodynamic therapy; Photosensitization; Photosensitizer; Photosensitizing Agents - pharmacology; Photosensitizing Agents - therapeutic use; Telomerase Inhibition; Telomeres; Tumors; Histone Deacetylase Inhibition; Nucleic Acid Damage; Telomerase Inhibition; Nuclear Targeting; Photosensitizer
• ISSN: 1433-7851; 1521-3773; 1521-3773
• DOI: 10.1002/anie.202114600

The nucleus is considered the ideal target for anti‐tumor therapy because DNA and some enzymes in the nucleus are the main causes of cell canceration and malignant proliferation. However, nuclear target drugs with good biosafety and high efficiency in cancer treatment are rare. Herein, a nuclear‐tar...