Mitochondrial ATP synthase β‐subunit production rate and ATP synthase specific activity are reduced in skeletal muscle of humans with obesity

• Published in: Experimental physiology Vol. 104; no. 1; pp. 126 - 135
• Main Authors: Tran, Lee, Langlais, Paul R., Hoffman, Nyssa, Roust, Lori, Katsanos, Christos S.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.01.2019
• Subjects: Adenosine triphosphatase; Adenosine Triphosphate - metabolism; adiposity; Adult; ATP synthase; Biopsy; Gene expression; Gene Expression - physiology; Humans; insulin resistance; Middle Aged; Mitochondria; Mitochondria - metabolism; Mitochondrial Proton-Translocating ATPases - metabolism; Muscle, Skeletal - metabolism; Obesity; Obesity - metabolism; protein synthesis; Skeletal muscle; protein synthesis; adiposity; insulin resistance; mitochondria

New Findings What is the central question of this study? Humans with obesity have lower ATP synthesis in muscle along with lower content of the β‐subunit of the ATP synthase (β‐F1‐ATPase), the catalytic component of the ATP synthase. Does lower synthesis rate of β‐F1‐ATPase in muscle contribute to t...