Design and development of a modified runway model of mouse drug self-administration

• Published in: Scientific reports Vol. 6; no. 1; p. 21944
• Main Authors: Pandy, Vijayapandi, Khan, Yasmin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.02.2016; Nature Publishing Group
• Subjects: 631/378/2649/1662; 64; 64/60; 692/308/2778; Animals; Behavior; Behavior, Animal; Biobehavioral Sciences - methods; Conditioning, Operant; Drug abuse; Drug addiction; Drug development; Drug dosages; Drug self-administration; Drug-Seeking Behavior; Ethanol; Ethanol - administration & dosage; Extinction, Psychological; Habituation; Habituation, Psychophysiologic; Heroin; Heroin - administration & dosage; Humanities and Social Sciences; Injections, Intraperitoneal; Laboratories; Male; Mice; Mice, Inbred ICR; Motivation; multidisciplinary; Nicotine; Nicotine - administration & dosage; Operant conditioning; Reinstatement; Rodents; Science; Self Administration - psychology; Substance-Related Disorders - physiopathology; Substance-Related Disorders - psychology

The present study established a novel mouse model of a runway drug self-administration in our laboratory. The operant runway apparatus consisted of three long runways arranged in a zig-zag manner. The methodology consisted of six distinct phases: habituation, preconditioning, conditioning, post-cond...